BRD-K50000283_PHA-767491_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K50000283_PHA-767491_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AHCYL1 adenosylhomocysteinase-like 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASPN asporin
BAG1 BCL2-associated athanogene
C1QTNF3 C1q and tumor necrosis factor related protein 3
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
COL5A2 collagen, type V, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CPD carboxypeptidase D
CPM carboxypeptidase M
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DBN1 drebrin 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
ESR2 estrogen receptor 2 (ER beta)
EXPH5 exophilin 5
F2R coagulation factor II (thrombin) receptor
FAM3C family with sequence similarity 3, member C
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABARAPL1 GABA(A) receptor-associated protein like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNS glucosamine (N-acetyl)-6-sulfatase
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER2 homer scaffolding protein 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
NELL2 NEL-like 2 (chicken)
NFE2L3 nuclear factor, erythroid 2-like 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
OPHN1 oligophrenin 1
PDE8B phosphodiesterase 8B
PLS3 plastin 3
PLXNB1 plexin B1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RAB2A RAB2A, member RAS oncogene family
REEP1 receptor accessory protein 1
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
RSAD2 radical S-adenosyl methionine domain containing 2
SCARB1 scavenger receptor class B, member 1
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SDPR serum deprivation response
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT6 septin 6
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
STC1 stanniocalcin 1
SYBU syntabulin (syntaxin-interacting)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNIK TRAF2 and NCK interacting kinase
TSPAN4 tetraspanin 4
WASF3 WAS protein family, member 3
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKR1C1 aldo-keto reductase family 1, member C1
ARMCX6 armadillo repeat containing, X-linked 6
ATMIN ATM interactor
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
FCGBP Fc fragment of IgG binding protein
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GLOD4 glyoxalase domain containing 4
GLS glutaminase
GLUL glutamate-ammonia ligase
H2AFX H2A histone family, member X
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IVNS1ABP influenza virus NS1A binding protein
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL18 methyltransferase like 18
MREG melanoregulin
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
OLFM1 olfactomedin 1
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPF4B pre-mRNA processing factor 4B
RAE1 ribonucleic acid export 1
RAN RAN, member RAS oncogene family
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RYBP RING1 and YY1 binding protein
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SNX5 sorting nexin 5
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TP63 tumor protein p63
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAM1 vascular cell adhesion molecule 1
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
ZIC1 Zic family member 1