BRD-K49865102_PD-0325901_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K49865102_PD-0325901_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AEBP1 AE binding protein 1
ALDOC aldolase C, fructose-bisphosphate
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
CD200 CD200 molecule
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CKM creatine kinase, muscle
CLIC5 chloride intracellular channel 5
CLU clusterin
COL1A1 collagen, type I, alpha 1
CTSK cathepsin K
DLK1 delta-like 1 homolog (Drosophila)
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
FCGBP Fc fragment of IgG binding protein
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HILPDA hypoxia inducible lipid droplet-associated
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
ISLR immunoglobulin superfamily containing leucine-rich repeat
ISYNA1 inositol-3-phosphate synthase 1
KANK1 KN motif and ankyrin repeat domains 1
KIF5C kinesin family member 5C
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
LPL lipoprotein lipase
MB myoglobin
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MMP3 matrix metallopeptidase 3
MUC16 mucin 16, cell surface associated
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NUPR1 nuclear protein, transcriptional regulator, 1
PCOLCE procollagen C-endopeptidase enhancer
PEX11A peroxisomal biogenesis factor 11 alpha
PPL periplakin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A1 S100 calcium binding protein A1
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC2 syndecan 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPRR3 small proline-rich protein 3
SYNE2 spectrin repeat containing, nuclear envelope 2
TCF4 transcription factor 4
TNS1 tensin 1
TRAF3IP2 TRAF3 interacting protein 2
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CHN1 chimerin 1
CRISP3 cysteine-rich secretory protein 3
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EPHA2 EPH receptor A2
EPHA3 EPH receptor A3
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUN jun proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MEOX2 mesenchyme homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NOV nephroblastoma overexpressed
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA2 paraneoplastic Ma antigen 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
SLC35G2 solute carrier family 35, member G2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLIT2 slit homolog 2 (Drosophila)
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D2 TSC22 domain family, member 2
TSPAN12 tetraspanin 12
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase
ZFP36L1 ZFP36 ring finger protein-like 1