BRD-K49865102_PD-0325901_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K49865102_PD-0325901_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
BID BH3 interacting domain death agonist
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CCR7 chemokine (C-C motif) receptor 7
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCA4 cell division cycle associated 4
CLCA4 chloride channel accessory 4
COL11A1 collagen, type XI, alpha 1
CRYAB crystallin, alpha B
CYTL1 cytokine-like 1
DBN1 drebrin 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPI glucose-6-phosphate isomerase
HIST1H1C histone cluster 1, H1c
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
METTL7A methyltransferase like 7A
MPO myeloperoxidase
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
NLRP2 NLR family, pyrin domain containing 2
NXN nucleoredoxin
OLFM4 olfactomedin 4
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2A phosphatidic acid phosphatase type 2A
PRAME preferentially expressed antigen in melanoma
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOBTB3 Rho-related BTB domain containing 3
RNF144A ring finger protein 144A
RRAGD Ras-related GTP binding D
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPON2 spondin 2, extracellular matrix protein
STAB1 stabilin 1
STOM stomatin
TBL1X transducin (beta)-like 1X-linked
TPD52L1 tumor protein D52-like 1
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AIM2 absent in melanoma 2
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
C3ORF14 chromosome 3 open reading frame 14
CCND1 cyclin D1
CCNL1 cyclin L1
CD1E CD1e molecule
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
ETV5 ets variant 5
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GSAP gamma-secretase activating protein
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER5 immediate early response 5
IL13RA2 interleukin 13 receptor, alpha 2
JAG1 jagged 1
JUN jun proto-oncogene
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
OSBPL8 oxysterol binding protein-like 8
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCZ protein kinase C, zeta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A6 solute carrier family 16, member 6
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TPBG trophoblast glycoprotein
TRBC1 T cell receptor beta constant 1
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VCAN versican
VEGFA vascular endothelial growth factor A