BRD-K49865102_PD-0325901_HCC515_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

443 genes differentially expressed following the BRD-K49865102_PD-0325901_HCC515_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMACR alpha-methylacyl-CoA racemase
AMDHD2 amidohydrolase domain containing 2
ANGPT1 angiopoietin 1
ANOS1 anosmin 1
ANXA2 annexin A2
AOX1 aldehyde oxidase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASRGL1 asparaginase like 1
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BLVRB biliverdin reductase B
BPGM 2,3-bisphosphoglycerate mutase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
C5 complement component 5
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELF2 CUGBP, Elav-like family member 2
CES1 carboxylesterase 1
CFB complement factor B
CFD complement factor D (adipsin)
CLDN10 claudin 10
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLG5 discs, large homolog 5 (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
DUSP3 dual specificity phosphatase 3
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F12 coagulation factor XII (Hageman factor)
FAM134B family with sequence similarity 134, member B
FBXL5 F-box and leucine-rich repeat protein 5
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GC group-specific component (vitamin D binding protein)
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HP haptoglobin
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL17RB interleukin 17 receptor B
ITGAV integrin, alpha V
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KLK5 kallikrein-related peptidase 5
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LITAF lipopolysaccharide-induced TNF factor
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MID1 midline 1
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MVP major vault protein
MX2 MX dynamin-like GTPase 2
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NNMT nicotinamide N-methyltransferase
NOTCH1 notch 1
NOV nephroblastoma overexpressed
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
ORM1 orosomucoid 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDZD2 PDZ domain containing 2
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PRSS23 protease, serine, 23
PXDN peroxidasin
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SFTPD surfactant protein D
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN2 stathmin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TJP2 tight junction protein 2
TM4SF4 transmembrane 4 L six family member 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR6 WD repeat domain 6
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ANK2 ankyrin 2, neuronal
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ANXA3 annexin A3
ANXA5 annexin A5
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
C7 complement component 7
CA2 carbonic anhydrase II
CALR calreticulin
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CCP110 centriolar coiled coil protein 110kDa
CD52 CD52 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL9A3 collagen, type IX, alpha 3
CRELD2 cysteine-rich with EGF-like domains 2
CSRP1 cysteine and glycine-rich protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL9 chemokine (C-X-C motif) ligand 9
CYTL1 cytokine-like 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFA4 defensin, alpha 4, corticostatin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DSG2 desmoglein 2
DST dystonin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR3 early growth response 3
EIF4E eukaryotic translation initiation factor 4E
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EPHA3 EPH receptor A3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBXO21 F-box protein 21
FBXO28 F-box protein 28
FERMT1 fermitin family member 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
FXYD6 FXYD domain containing ion transport regulator 6
FZD10 frizzled class receptor 10
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLI2 GLI family zinc finger 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
GPER1 G protein-coupled estrogen receptor 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBEGF heparin-binding EGF-like growth factor
HIRA histone cell cycle regulator
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HNMT histamine N-methyltransferase
HOPX HOP homeobox
HPCAL1 hippocalcin-like 1
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
IL7R interleukin 7 receptor
ISLR immunoglobulin superfamily containing leucine-rich repeat
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
MTA1 metastasis associated 1
MYH11 myosin, heavy chain 11, smooth muscle
NEFL neurofilament, light polypeptide
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NOP2 NOP2 nucleolar protein
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK1 polo-like kinase 1
PLN phospholamban
PMP22 peripheral myelin protein 22
PPARG peroxisome proliferator-activated receptor gamma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
PTX3 pentraxin 3, long
RAD51AP1 RAD51 associated protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOBP sine oculis binding protein homolog (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SRPK1 SRSF protein kinase 1
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TCF21 transcription factor 21
THBD thrombomodulin
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPI1 triosephosphate isomerase 1
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
WSB2 WD repeat and SOCS box containing 2
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZEB1 zinc finger E-box binding homeobox 1