BRD-K49865102_PD-0325901_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K49865102_PD-0325901_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALB albumin
APOL1 apolipoprotein L, 1
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
C3 complement component 3
C5AR1 complement component 5a receptor 1
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CFB complement factor B
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
DACH1 dachshund family transcription factor 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMX2 empty spiracles homeobox 2
FPR1 formyl peptide receptor 1
FYB FYN binding protein
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
HIST1H2BD histone cluster 1, H2bd
HLA-DMA major histocompatibility complex, class II, DM alpha
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KRT19 keratin 19, type I
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
METTL7A methyltransferase like 7A
MX2 MX dynamin-like GTPase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PRUNE2 prune homolog 2 (Drosophila)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RHOBTB1 Rho-related BTB domain containing 1
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STK38 serine/threonine kinase 38
THAP11 THAP domain containing 11
TLR4 toll-like receptor 4
TMEM100 transmembrane protein 100
TMPRSS4 transmembrane protease, serine 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
C2CD5 C2 calcium-dependent domain containing 5
CAB39 calcium binding protein 39
CALML5 calmodulin-like 5
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CD81 CD81 molecule
CDC42 cell division cycle 42
CSRP1 cysteine and glycine-rich protein 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GEM GTP binding protein overexpressed in skeletal muscle
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IER2 immediate early response 2
IER3 immediate early response 3
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KRT6B keratin 6B, type II
LYPLA1 lysophospholipase I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
NFIB nuclear factor I/B
NT5E 5'-nucleotidase, ecto (CD73)
OLA1 Obg-like ATPase 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
PON3 paraoxonase 3
PPA1 pyrophosphatase (inorganic) 1
PRDX4 peroxiredoxin 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTRF polymerase I and transcript release factor
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNJ2 synaptojanin 2
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon