BRD-K49669041_BX-912_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K49669041_BX-912_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
BCL2A1 BCL2-related protein A1
BICD2 bicaudal D homolog 2 (Drosophila)
BIRC3 baculoviral IAP repeat containing 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSL cathepsin L
CTSS cathepsin S
CXCL3 chemokine (C-X-C motif) ligand 3
CYTH1 cytohesin 1
DCTD dCMP deaminase
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DSC1 desmocollin 1
DSG1 desmoglein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FZD5 frizzled class receptor 5
GAL galanin/GMAP prepropeptide
GLRX glutaredoxin (thioltransferase)
GOLIM4 golgi integral membrane protein 4
GRN granulin
GSN gelsolin
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2BK histone cluster 1, H2bk
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
INSM1 insulinoma-associated 1
ITGB5 integrin, beta 5
KLF5 Kruppel-like factor 5 (intestinal)
KLF9 Kruppel-like factor 9
LCE2B late cornified envelope 2B
LOR loricrin
LYZ lysozyme
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MMP9 matrix metallopeptidase 9
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PERP PERP, TP53 apoptosis effector
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYGL phosphorylase, glycogen, liver
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SGK1 serum/glucocorticoid regulated kinase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TAPBP TAP binding protein (tapasin)
TARP TCR gamma alternate reading frame protein
TATDN2 TatD DNase domain containing 2
TCEA2 transcription elongation factor A (SII), 2
TESC tescalcin
TFF1 trefoil factor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TSC22D1 TSC22 domain family, member 1
TYRP1 tyrosinase-related protein 1

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ARFIP2 ADP-ribosylation factor interacting protein 2
BIK BCL2-interacting killer (apoptosis-inducing)
CD44 CD44 molecule (Indian blood group)
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CORO1A coronin, actin binding protein, 1A
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ETV5 ets variant 5
FGFR2 fibroblast growth factor receptor 2
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GBAP1 glucosidase, beta, acid pseudogene 1
GOLGA8A golgin A8 family, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP3 glucuronidase, beta pseudogene 3
H2AFX H2A histone family, member X
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOMER3 homer scaffolding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL17RB interleukin 17 receptor B
KIAA0101 KIAA0101
KIAA1033 KIAA1033
KRT19 keratin 19, type I
LPCAT1 lysophosphatidylcholine acyltransferase 1
MEA1 male-enhanced antigen 1
MRPL49 mitochondrial ribosomal protein L49
MRPL57 mitochondrial ribosomal protein L57
MRPS16 mitochondrial ribosomal protein S16
MSRB1 methionine sulfoxide reductase B1
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT1 nitrilase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PEG10 paternally expressed 10
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLS1 plastin 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
RBM15B RNA binding motif protein 15B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
THTPA thiamine triphosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
UBE2A ubiquitin-conjugating enzyme E2A
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
ZBTB16 zinc finger and BTB domain containing 16
ZWINT ZW10 interacting kinetochore protein