BRD-K49669041_BX-912_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K49669041_BX-912_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHLHE40 basic helix-loop-helix family, member e40
C1ORF54 chromosome 1 open reading frame 54
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CBX1 chromobox homolog 1
CCL21 chemokine (C-C motif) ligand 21
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CETN2 centrin, EF-hand protein, 2
CHPT1 choline phosphotransferase 1
CIB1 calcium and integrin binding 1 (calmyrin)
CLC Charcot-Leyden crystal galectin
CLDN10 claudin 10
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRLF1 cytokine receptor-like factor 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DMBT1 deleted in malignant brain tumors 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
FYB FYN binding protein
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LPL lipoprotein lipase
LYZ lysozyme
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MPPED2 metallophosphoesterase domain containing 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NGRN neugrin, neurite outgrowth associated
NME5 NME/NM23 family member 5
NPR3 natriuretic peptide receptor 3
NPTX2 neuronal pentraxin II
NTS neurotensin
OSBPL9 oxysterol binding protein-like 9
PCDH17 protocadherin 17
PCOLCE procollagen C-endopeptidase enhancer
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB21 RAB21, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A2 S100 calcium binding protein A2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFTPB surfactant protein B
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STC2 stanniocalcin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TOB1 transducer of ERBB2, 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TREM1 triggering receptor expressed on myeloid cells 1
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AMOTL2 angiomotin like 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BMP4 bone morphogenetic protein 4
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL4 chemokine (C-C motif) ligand 4
CCNF cyclin F
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COL13A1 collagen, type XIII, alpha 1
CREB1 cAMP responsive element binding protein 1
CXCL11 chemokine (C-X-C motif) ligand 11
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
EGR2 early growth response 2
FOSL1 FOS-like antigen 1
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GBP1 guanylate binding protein 1, interferon-inducible
GPATCH8 G patch domain containing 8
HMGA2 high mobility group AT-hook 2
IFI16 interferon, gamma-inducible protein 16
IFNG interferon, gamma
INSM1 insulinoma-associated 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KIZ kizuna centrosomal protein
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV2 neuron navigator 2
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PKP2 plakophilin 2
PODXL podocalyxin-like
PPP1R10 protein phosphatase 1, regulatory subunit 10
PROM1 prominin 1
PSRC1 proline/serine-rich coiled-coil 1
RAI14 retinoic acid induced 14
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
ST18 suppression of tumorigenicity 18, zinc finger
SYNJ2 synaptojanin 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
ZHX2 zinc fingers and homeoboxes 2
ZNF451 zinc finger protein 451