BRD-K49669041_BX-912_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K49669041_BX-912_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKAP8L A kinase (PRKA) anchor protein 8-like
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASCL1 achaete-scute family bHLH transcription factor 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
EHBP1L1 EH domain binding protein 1-like 1
EZR ezrin
FKBP1A FK506 binding protein 1A, 12kDa
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD2 FXYD domain containing ion transport regulator 2
GDF15 growth differentiation factor 15
GMDS GDP-mannose 4,6-dehydratase
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
JAG1 jagged 1
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSP1 lymphocyte-specific protein 1
MAOB monoamine oxidase B
MMP7 matrix metallopeptidase 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NPY neuropeptide Y
NUTF2 nuclear transport factor 2
PAM peptidylglycine alpha-amidating monooxygenase
PDZK1IP1 PDZK1 interacting protein 1
PRAME preferentially expressed antigen in melanoma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RGS4 regulator of G-protein signaling 4
S100A10 S100 calcium binding protein A10
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SNX11 sorting nexin 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52 tumor protein D52
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VCAN versican

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANKRD28 ankyrin repeat domain 28
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASS1 argininosuccinate synthase 1
ASXL2 additional sex combs like transcriptional regulator 2
ATF1 activating transcription factor 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
C2CD5 C2 calcium-dependent domain containing 5
CCND2 cyclin D2
CCNF cyclin F
CEP350 centrosomal protein 350kDa
CHD9 chromodomain helicase DNA binding protein 9
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
EFNA1 ephrin-A1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EXPH5 exophilin 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
IFRD2 interferon-related developmental regulator 2
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIAA1033 KIAA1033
KRCC1 lysine-rich coiled-coil 1
LIMK2 LIM domain kinase 2
LYST lysosomal trafficking regulator
MED13 mediator complex subunit 13
MICALL1 MICAL-like 1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MTDH metadherin
MYO5C myosin VC
MYO6 myosin VI
NRCAM neuronal cell adhesion molecule
NUP62 nucleoporin 62kDa
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCM1 pericentriolar material 1
PHIP pleckstrin homology domain interacting protein
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPP1R10 protein phosphatase 1, regulatory subunit 10
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS2 regulator of G-protein signaling 2
RXRA retinoid X receptor, alpha
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM2 transmembrane protein 2
TNS3 tensin 3
TOR1A torsin family 1, member A (torsin A)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAV3 vav 3 guanine nucleotide exchange factor
ZBTB20 zinc finger and BTB domain containing 20
ZC3H4 zinc finger CCCH-type containing 4
ZEB1 zinc finger E-box binding homeobox 1
ZNF217 zinc finger protein 217