BRD-K49669041_BX-912_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K49669041_BX-912_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ANXA6 annexin A6
APOD apolipoprotein D
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BGN biglycan
C3ORF14 chromosome 3 open reading frame 14
CAPG capping protein (actin filament), gelsolin-like
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSS cathepsin S
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EVI2B ecotropic viral integration site 2B
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOPX HOP homeobox
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LSP1 lymphocyte-specific protein 1
LXN latexin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL10 oxysterol binding protein-like 10
PDZK1IP1 PDZK1 interacting protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PRKCD protein kinase C, delta
PROM1 prominin 1
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
RPL39L ribosomal protein L39-like
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TRIL TLR4 interactor with leucine-rich repeats
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1

decreased expression

Symbol Name
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRB2 adrenoceptor beta 2, surface
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUNIP aurora kinase A and ninein interacting protein
AURKB aurora kinase B
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DCT dopachrome tautomerase
DHFR dihydrofolate reductase
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELANE elastase, neutrophil expressed
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GTSE1 G-2 and S-phase expressed 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBE1 hemoglobin, epsilon 1
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
JMJD6 jumonji domain containing 6
KIF18B kinesin family member 18B
LMNB1 lamin B1
MAOB monoamine oxidase B
MCM10 minichromosome maintenance complex component 10
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYLK myosin light chain kinase
NOP16 NOP16 nucleolar protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
RAD23B RAD23 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RNF167 ring finger protein 167
RPL10 ribosomal protein L10
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCARB1 scavenger receptor class B, member 1
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TF transferrin
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S