BRD-K49669041_BX-912_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-K49669041_BX-912_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ACOT9 acyl-CoA thioesterase 9
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOD apolipoprotein D
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNB2 cyclin B2
CCNG2 cyclin G2
CD9 CD9 molecule
CHEK2 checkpoint kinase 2
CLU clusterin
CNOT8 CCR4-NOT transcription complex, subunit 8
CPB1 carboxypeptidase B1 (tissue)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
DAZAP2 DAZ associated protein 2
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DUSP22 dual specificity phosphatase 22
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F11R F11 receptor
FBXW11 F-box and WD repeat domain containing 11
FGFR1 fibroblast growth factor receptor 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLNB filamin B, beta
FOXC1 forkhead box C1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GM2A GM2 ganglioside activator
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HBD hemoglobin, delta
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
LHX2 LIM homeobox 2
LINC00341 long intergenic non-protein coding RNA 341
LPAR6 lysophosphatidic acid receptor 6
LSP1 lymphocyte-specific protein 1
LTF lactotransferrin
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K1 mitogen-activated protein kinase kinase 1
MCTP1 multiple C2 domains, transmembrane 1
METTL7A methyltransferase like 7A
MMD monocyte to macrophage differentiation-associated
MMP9 matrix metallopeptidase 9
MOB1A MOB kinase activator 1A
MPZL1 myelin protein zero-like 1
NDC80 NDC80 kinetochore complex component
NDRG1 N-myc downstream regulated 1
NEK2 NIMA-related kinase 2
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXT2 nuclear transport factor 2-like export factor 2
PBX1 pre-B-cell leukemia homeobox 1
PCBP2 poly(rC) binding protein 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PI3 peptidase inhibitor 3, skin-derived
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
PRNP prion protein
PRR7 proline rich 7 (synaptic)
QKI QKI, KH domain containing, RNA binding
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBM47 RNA binding motif protein 47
REEP5 receptor accessory protein 5
RHOF ras homolog family member F (in filopodia)
RPL31 ribosomal protein L31
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMAD3 SMAD family member 3
SMIM7 small integral membrane protein 7
SSBP2 single-stranded DNA binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TGFBR3 transforming growth factor, beta receptor III
TNIP1 TNFAIP3 interacting protein 1
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
USP3 ubiquitin specific peptidase 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHR aryl hydrocarbon receptor
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ASCC3 activating signal cointegrator 1 complex subunit 3
CALD1 caldesmon 1
CAV2 caveolin 2
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CH25H cholesterol 25-hydroxylase
CIRBP cold inducible RNA binding protein
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COA3 cytochrome c oxidase assembly factor 3
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COPS6 COP9 signalosome subunit 6
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DMBT1 deleted in malignant brain tumors 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INA internexin neuronal intermediate filament protein, alpha
INHBA inhibin, beta A
IPO4 importin 4
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MANSC1 MANSC domain containing 1
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MEA1 male-enhanced antigen 1
MEG3 maternally expressed 3 (non-protein coding)
MET MET proto-oncogene, receptor tyrosine kinase
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYO1B myosin IB
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNT nicotinamide nucleotide transhydrogenase
NT5E 5'-nucleotidase, ecto (CD73)
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PALLD palladin, cytoskeletal associated protein
PLAU plasminogen activator, urokinase
PLS3 plastin 3
PNKP polynucleotide kinase 3'-phosphatase
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPB surfactant protein B
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SMYD3 SET and MYND domain containing 3
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
SUB1 SUB1 homolog (S. cerevisiae)
SULF1 sulfatase 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TGM2 transglutaminase 2
THBS1 thrombospondin 1
THTPA thiamine triphosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TOM1L1 target of myb1 (chicken)-like 1
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TRIP6 thyroid hormone receptor interactor 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
VSNL1 visinin-like 1
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein