BRD-K49669041_BX-912_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K49669041_BX-912_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACB acetyl-CoA carboxylase beta
ADD3 adducin 3 (gamma)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
APLP2 amyloid beta (A4) precursor-like protein 2
ATP9A ATPase, class II, type 9A
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BST2 bone marrow stromal cell antigen 2
CCDC28A coiled-coil domain containing 28A
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CTSB cathepsin B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
DDB2 damage-specific DNA binding protein 2, 48kDa
E2F2 E2F transcription factor 2
EFNA1 ephrin-A1
FGFR2 fibroblast growth factor receptor 2
GRAMD1C GRAM domain containing 1C
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HLA-B major histocompatibility complex, class I, B
ICAM1 intercellular adhesion molecule 1
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
LUC7L3 LUC7-like 3 (S. cerevisiae)
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
NAV2 neuron navigator 2
NLRP2 NLR family, pyrin domain containing 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
PBX1 pre-B-cell leukemia homeobox 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBM47 RNA binding motif protein 47
RGS2 regulator of G-protein signaling 2
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERINC3 serine incorporator 3
SOD1 superoxide dismutase 1, soluble
SRGN serglycin
TCEA2 transcription elongation factor A (SII), 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP63 tumor protein p63
VGLL4 vestigial-like family member 4
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHD7 chromodomain helicase DNA binding protein 7
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDNRB endothelin receptor type B
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP16 NOP16 nucleolar protein
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLN phospholamban
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PRSS23 protease, serine, 23
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT11 septin 11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMTN smoothelin
SNAI2 snail family zinc finger 2
SQLE squalene epoxidase
STC1 stanniocalcin 1
TFF1 trefoil factor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS1 thrombospondin 1
THSD7A thrombospondin, type I, domain containing 7A
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TSC22D2 TSC22 domain family, member 2
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1