BRD-K49669041_BX-912_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K49669041_BX-912_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
BTG2 BTG family, member 2
C14ORF159 chromosome 14 open reading frame 159
CCL5 chemokine (C-C motif) ligand 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSW cathepsin W
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
EIF5A eukaryotic translation initiation factor 5A
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GJA1 gap junction protein, alpha 1, 43kDa
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSPB8 heat shock 22kDa protein 8
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2A integral membrane protein 2A
KIAA0753 KIAA0753
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
NRIP1 nuclear receptor interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PLCB4 phospholipase C, beta 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
REEP1 receptor accessory protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SPATA20 spermatogenesis associated 20
STAB1 stabilin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TARP TCR gamma alternate reading frame protein
TFPI2 tissue factor pathway inhibitor 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNNT1 troponin T type 1 (skeletal, slow)
TRIM22 tripartite motif containing 22
TUSC3 tumor suppressor candidate 3
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AEBP1 AE binding protein 1
ALDOB aldolase B, fructose-bisphosphate
ATAD2 ATPase family, AAA domain containing 2
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CXCR4 chemokine (C-X-C motif) receptor 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK4 dickkopf WNT signaling pathway inhibitor 4
FABP1 fatty acid binding protein 1, liver
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAL histidine ammonia-lyase
HLA-DRA major histocompatibility complex, class II, DR alpha
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF18B kinesin family member 18B
KNG1 kininogen 1
KRT23 keratin 23, type I
LEF1 lymphoid enhancer-binding factor 1
LINC00341 long intergenic non-protein coding RNA 341
LTF lactotransferrin
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MMP12 matrix metallopeptidase 12
MYB v-myb avian myeloblastosis viral oncogene homolog
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
PROM1 prominin 1
PRSS3 protease, serine, 3
RUNX1 runt-related transcription factor 1
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TAGLN transgelin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFRC transferrin receptor
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNC tenascin C
VTCN1 V-set domain containing T cell activation inhibitor 1