BRD-K49328571_dasatinib_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

401 genes differentially expressed following the BRD-K49328571_dasatinib_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADCK3 aarF domain containing kinase 3
ADGRF5 adhesion G protein-coupled receptor F5
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANGPT1 angiopoietin 1
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACE2 beta-site APP-cleaving enzyme 2
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
BHLHE41 basic helix-loop-helix family, member e41
BTBD3 BTB (POZ) domain containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
C5 complement component 5
CADPS2 Ca++-dependent secretion activator 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP70 centrosomal protein 70kDa
CFI complement factor I
CHGB chromogranin B
CHN1 chimerin 1
CLDN10 claudin 10
COCH cochlin
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPD carboxypeptidase D
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CYB561 cytochrome b561
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPN2 epsin 2
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV1 ets variant 1
EXPH5 exophilin 5
F5 coagulation factor V (proaccelerin, labile factor)
FADS2 fatty acid desaturase 2
FAM46A family with sequence similarity 46, member A
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
GAB2 GRB2-associated binding protein 2
GATA2 GATA binding protein 2
GLDC glycine dehydrogenase (decarboxylating)
GPATCH8 G patch domain containing 8
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HNMT histamine N-methyltransferase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOOK2 hook microtubule-tethering protein 2
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
ISL1 ISL LIM homeobox 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0485 uncharacterized LOC57235
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
KYNU kynureninase
LAMB1 laminin, beta 1
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LPIN1 lipin 1
LRRC16A leucine rich repeat containing 16A
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAGEA12 melanoma antigen family A12
MAN2B2 mannosidase, alpha, class 2B, member 2
MAOB monoamine oxidase B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAST2 microtubule associated serine/threonine kinase 2
MBNL2 muscleblind-like splicing regulator 2
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MLPH melanophilin
MOXD1 monooxygenase, DBH-like 1
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MYH11 myosin, heavy chain 11, smooth muscle
MYO6 myosin VI
MYRF myelin regulatory factor
NDRG1 N-myc downstream regulated 1
NET1 neuroepithelial cell transforming 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OBSL1 obscurin-like 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSR2 odd-skipped related transciption factor 2
PAQR6 progestin and adipoQ receptor family member VI
PCDH9 protocadherin 9
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PKP4 plakophilin 4
PLN phospholamban
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PRRC2C proline-rich coiled-coil 2C
PSCA prostate stem cell antigen
PTCH1 patched 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RET ret proto-oncogene
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMYD3 SET and MYND domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STK26 serine/threonine protein kinase 26
STXBP2 syntaxin binding protein 2
SYNM synemin, intermediate filament protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TECR trans-2,3-enoyl-CoA reductase
TESC tescalcin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE4 transducin-like enhancer of split 4
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIK TRAF2 and NCK interacting kinase
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
WFDC1 WAP four-disulfide core domain 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
XK X-linked Kx blood group
XYLT1 xylosyltransferase I
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ACTC1 actin, alpha, cardiac muscle 1
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
AXL AXL receptor tyrosine kinase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL4 chemokine (C-C motif) ligand 4
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNE1 cyclin E1
CCNE2 cyclin E2
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDA cytidine deaminase
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CES1 carboxylesterase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COPS7A COP9 signalosome subunit 7A
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DES desmin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOK5 docking protein 5
DPT dermatopontin
DSE dermatan sulfate epimerase
DSG2 desmoglein 2
DUSP2 dual specificity phosphatase 2
DUSP7 dual specificity phosphatase 7
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
FZD2 frizzled class receptor 2
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GPR88 G protein-coupled receptor 88
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
INHBB inhibin, beta B
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAL mal, T-cell differentiation protein
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MBP myelin basic protein
MCAM melanoma cell adhesion molecule
MCL1 myeloid cell leukemia 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MRPL57 mitochondrial ribosomal protein L57
MT1E metallothionein 1E
MT1M metallothionein 1M
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOV nephroblastoma overexpressed
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUSAP1 nucleolar and spindle associated protein 1
PAPD7 PAP associated domain containing 7
PBK PDZ binding kinase
PEA15 phosphoprotein enriched in astrocytes 15
PENK proenkephalin
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMM2 phosphomannomutase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PSPH phosphoserine phosphatase
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTHLH parathyroid hormone-like hormone
PTX3 pentraxin 3, long
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SAP18 Sin3A-associated protein, 18kDa
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SPON1 spondin 1, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRI sorcin
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIGAR TP53 induced glycolysis regulatory phosphatase
TMSB15A thymosin beta 15a
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TUBB6 tubulin, beta 6 class V
UGDH UDP-glucose 6-dehydrogenase
VAV3 vav 3 guanine nucleotide exchange factor
VGLL4 vestigial-like family member 4
WDR7 WD repeat domain 7
WIF1 WNT inhibitory factor 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM2 zinc finger, MYM-type 2