BRD-K49328571_dasatinib_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K49328571_dasatinib_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACP5 acid phosphatase 5, tartrate resistant
AKR1C3 aldo-keto reductase family 1, member C3
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C14ORF132 chromosome 14 open reading frame 132
CBS cystathionine-beta-synthase
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNOT4 CCR4-NOT transcription complex, subunit 4
COBL cordon-bleu WH2 repeat protein
CREM cAMP responsive element modulator
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DUSP4 dual specificity phosphatase 4
E2F2 E2F transcription factor 2
EFNA1 ephrin-A1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM168A family with sequence similarity 168, member A
FGL2 fibrinogen-like 2
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP4 low density lipoprotein receptor-related protein 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NREP neuronal regeneration related protein
OBSL1 obscurin-like 1
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PSAT1 phosphoserine aminotransferase 1
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SFTPD surfactant protein D
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SPRED2 sprouty-related, EVH1 domain containing 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TBL1X transducin (beta)-like 1X-linked
TMEM2 transmembrane protein 2
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
USP6NL USP6 N-terminal like
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ARG1 arginase 1
BMP4 bone morphogenetic protein 4
CADM1 cell adhesion molecule 1
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP14 dual specificity phosphatase 14
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FST follistatin
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HOPX HOP homeobox
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXC6 homeobox C6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDS iduronate 2-sulfatase
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IL6ST interleukin 6 signal transducer
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
LTF lactotransferrin
MCUR1 mitochondrial calcium uniporter regulator 1
MIR22HG MIR22 host gene
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRN1 neuritin 1
PDGFD platelet derived growth factor D
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
RELN reelin
RPS4Y1 ribosomal protein S4, Y-linked 1
SCRG1 stimulator of chondrogenesis 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
VCAM1 vascular cell adhesion molecule 1