BRD-K49328571_dasatinib_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K49328571_dasatinib_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAM28 ADAM metallopeptidase domain 28
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
APOD apolipoprotein D
ARG2 arginase 2
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CCDC47 coiled-coil domain containing 47
CCNG2 cyclin G2
CD93 CD93 molecule
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
FGFR2 fibroblast growth factor receptor 2
FKBP5 FK506 binding protein 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FRZB frizzled-related protein
FZD7 frizzled class receptor 7
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNMT histamine N-methyltransferase
HOXA5 homeobox A5
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1R insulin-like growth factor 1 receptor
IL17RB interleukin 17 receptor B
IRS2 insulin receptor substrate 2
KAZN kazrin, periplakin interacting protein
KLK6 kallikrein-related peptidase 6
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MSX1 msh homeobox 1
MTUS1 microtubule associated tumor suppressor 1
NCOA2 nuclear receptor coactivator 2
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
OLFM1 olfactomedin 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SOD2 superoxide dismutase 2, mitochondrial
SRGN serglycin
SYNE2 spectrin repeat containing, nuclear envelope 2
TCF4 transcription factor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AMDHD2 amidohydrolase domain containing 2
AMOTL2 angiomotin like 2
ANGPT1 angiopoietin 1
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
AXL AXL receptor tyrosine kinase
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C3AR1 complement component 3a receptor 1
CA1 carbonic anhydrase I
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL4A5 collagen, type IV, alpha 5
CST6 cystatin E/M
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUOX1 dual oxidase 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EFNB2 ephrin-B2
EGR3 early growth response 3
EHD1 EH-domain containing 1
EIF4A1 eukaryotic translation initiation factor 4A1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1B interleukin 1, beta
IL6 interleukin 6
INHBA inhibin, beta A
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUN jun proto-oncogene
KIF5B kinesin family member 5B
KRT18 keratin 18, type I
KYNU kynureninase
LAPTM5 lysosomal protein transmembrane 5
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
MEG3 maternally expressed 3 (non-protein coding)
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMB microseminoprotein, beta-
MYLK myosin light chain kinase
NEBL nebulette
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
OSBPL8 oxysterol binding protein-like 8
PAWR PRKC, apoptosis, WT1, regulator
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEC plectin
PMEPA1 prostate transmembrane protein, androgen induced 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTRF polymerase I and transcript release factor
RPIA ribose 5-phosphate isomerase A
SATB1 SATB homeobox 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAP25 synaptosomal-associated protein, 25kDa
SPAG4 sperm associated antigen 4
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
STARD13 StAR-related lipid transfer (START) domain containing 13
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TTC3 tetratricopeptide repeat domain 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
URI1 URI1, prefoldin-like chaperone
ZBED2 zinc finger, BED-type containing 2
ZNF395 zinc finger protein 395