BRD-K49075727_nintedanib_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K49075727_nintedanib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ADGRG2 adhesion G protein-coupled receptor G2
AMPD3 adenosine monophosphate deaminase 3
ANXA1 annexin A1
ANXA3 annexin A3
ANXA6 annexin A6
AXL AXL receptor tyrosine kinase
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTN3A2 butyrophilin, subfamily 3, member A2
C1ORF106 chromosome 1 open reading frame 106
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CAPN3 calpain 3, (p94)
CCNA1 cyclin A1
COL11A1 collagen, type XI, alpha 1
CTSH cathepsin H
CTSL cathepsin L
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DRAM1 DNA-damage regulated autophagy modulator 1
EZR ezrin
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
LAMC2 laminin, gamma 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC15 leucine rich repeat containing 15
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAM maltase-glucoamylase
MGLL monoglyceride lipase
NPR3 natriuretic peptide receptor 3
PDGFC platelet derived growth factor C
PFKM phosphofructokinase, muscle
PHGDH phosphoglycerate dehydrogenase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS1 plastin 1
PLS3 plastin 3
PNMA2 paraneoplastic Ma antigen 2
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYGL phosphorylase, glycogen, liver
RGS10 regulator of G-protein signaling 10
RUFY3 RUN and FYVE domain containing 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STXBP1 syntaxin binding protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM14 tripartite motif containing 14
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
TYROBP TYRO protein tyrosine kinase binding protein
UGCG UDP-glucose ceramide glucosyltransferase
VIM vimentin

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
BAMBI BMP and activin membrane-bound inhibitor
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD24 CD24 molecule
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP10 dual specificity phosphatase 10
EAF2 ELL associated factor 2
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HOXA10 homeobox A10
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
KRT15 keratin 15, type I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MYH11 myosin, heavy chain 11, smooth muscle
NR2F1 nuclear receptor subfamily 2, group F, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RND3 Rho family GTPase 3
SATB1 SATB homeobox 1
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SNAP25 synaptosomal-associated protein, 25kDa
TAC1 tachykinin, precursor 1
VPREB3 pre-B lymphocyte 3
VWF von Willebrand factor
ZFP36L2 ZFP36 ring finger protein-like 2