BRD-K49075727_nintedanib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K49075727_nintedanib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAMBI BMP and activin membrane-bound inhibitor
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
CCNG2 cyclin G2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFI complement factor I
CHRDL1 chordin-like 1
CLU clusterin
CTSS cathepsin S
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL5 ELOVL fatty acid elongase 5
EMP2 epithelial membrane protein 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FRY furry homolog (Drosophila)
GLUL glutamate-ammonia ligase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LGALS8 lectin, galactoside-binding, soluble, 8
MANSC1 MANSC domain containing 1
MATN2 matrilin 2
MEGF9 multiple EGF-like-domains 9
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NOV nephroblastoma overexpressed
OPTN optineurin
PEG10 paternally expressed 10
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
S100A4 S100 calcium binding protein A4
SALL2 spalt-like transcription factor 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCE sarcoglycan, epsilon
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SORBS1 sorbin and SH3 domain containing 1
SPP1 secreted phosphoprotein 1
SQRDL sulfide quinone reductase-like (yeast)
STOM stomatin
STON1 stonin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYBU syntabulin (syntaxin-interacting)
TKT transketolase
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TUBB2B tubulin, beta 2B class IIb
USP6NL USP6 N-terminal like

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CCNE2 cyclin E2
CCR7 chemokine (C-C motif) receptor 7
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CYTH1 cytohesin 1
DSP desmoplakin
ELL2 elongation factor, RNA polymerase II, 2
FAP fibroblast activation protein, alpha
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
IL7R interleukin 7 receptor
IRX5 iroquois homeobox 5
KRT81 keratin 81, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
MIR22HG MIR22 host gene
MMP2 matrix metallopeptidase 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAV3 neuron navigator 3
PDGFA platelet-derived growth factor alpha polypeptide
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
RPP40 ribonuclease P/MRP 40kDa subunit
SEC23A Sec23 homolog A (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
SYNJ2 synaptojanin 2
THBS1 thrombospondin 1
TRAF3IP3 TRAF3 interacting protein 3
TRBC1 T cell receptor beta constant 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A