BRD-K49010888_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K49010888_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANGPTL2 angiopoietin-like 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATM ATM serine/threonine kinase
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
C1QB complement component 1, q subcomponent, B chain
CCDC92 coiled-coil domain containing 92
CD14 CD14 molecule
CD163 CD163 molecule
CD24 CD24 molecule
CD93 CD93 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHN2 chimerin 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COMP cartilage oligomeric matrix protein
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTSB cathepsin B
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EFHD1 EF-hand domain family, member D1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EVI2A ecotropic viral integration site 2A
FAIM Fas apoptotic inhibitory molecule
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FRZB frizzled-related protein
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8H golgin A8 family, member H
GPRC5B G protein-coupled receptor, class C, group 5, member B
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
KIAA0226L KIAA0226-like
KRT81 keratin 81, type II
LPAR6 lysophosphatidic acid receptor 6
MAP2K6 mitogen-activated protein kinase kinase 6
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
NLGN4X neuroligin 4, X-linked
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML3 olfactomedin-like 3
PADI2 peptidyl arginine deiminase, type II
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PNMAL1 paraneoplastic Ma antigen family-like 1
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RGCC regulator of cell cycle
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TRIM2 tripartite motif containing 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
C8ORF4 chromosome 8 open reading frame 4
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL4A5 collagen, type IV, alpha 5
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
GAL galanin/GMAP prepropeptide
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LSR lipolysis stimulated lipoprotein receptor
LYPD1 LY6/PLAUR domain containing 1
MAGEA1 melanoma antigen family A1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MBOAT7 membrane bound O-acyltransferase domain containing 7
MSLN mesothelin
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
RAD23B RAD23 homolog B (S. cerevisiae)
RFTN1 raftlin, lipid raft linker 1
RGS4 regulator of G-protein signaling 4
TLR4 toll-like receptor 4
TMOD1 tropomodulin 1
TRIB2 tribbles pseudokinase 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1