BRD-K48488978_YM-201636_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K48488978_YM-201636_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
BCL6 B-cell CLL/lymphoma 6
CAPN3 calpain 3, (p94)
CD163 CD163 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CES2 carboxylesterase 2
CHMP6 charged multivesicular body protein 6
COL10A1 collagen, type X, alpha 1
CST1 cystatin SN
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
ENO2 enolase 2 (gamma, neuronal)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPM6B glycoprotein M6B
GRN granulin
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
INHBB inhibin, beta B
IRF7 interferon regulatory factor 7
ISLR immunoglobulin superfamily containing leucine-rich repeat
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC15 leucine rich repeat containing 15
METRN meteorin, glial cell differentiation regulator
MMP11 matrix metallopeptidase 11
MRPS16 mitochondrial ribosomal protein S16
MVP major vault protein
MX1 MX dynamin-like GTPase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OLFML3 olfactomedin-like 3
PAWR PRKC, apoptosis, WT1, regulator
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLXNC1 plexin C1
PSPH phosphoserine phosphatase
RHOB ras homolog family member B
RORA RAR-related orphan receptor A
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFE3 transcription factor binding to IGHM enhancer 3
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ANXA1 annexin A1
BZW2 basic leucine zipper and W2 domains 2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD9 CD9 molecule
CDC45 cell division cycle 45
CPB1 carboxypeptidase B1 (tissue)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKC1 dyskeratosis congenita 1, dyskerin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENOPH1 enolase-phosphatase 1
FN1 fibronectin 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA14 heat shock 70kDa protein 14
IFRD2 interferon-related developmental regulator 2
ITM2A integral membrane protein 2A
KRT17 keratin 17, type I
LCN2 lipocalin 2
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAK1IP1 PAK1 interacting protein 1
PEG3 paternally expressed 3
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PTDSS1 phosphatidylserine synthase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPP38 ribonuclease P/MRP 38kDa subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SRM spermidine synthase
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TRIP13 thyroid hormone receptor interactor 13