BRD-K47983010_BX-795_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K47983010_BX-795_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
APOD apolipoprotein D
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
CST1 cystatin SN
CST4 cystatin S
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP6 dual specificity phosphatase 6
ETV1 ets variant 1
ETV5 ets variant 5
FBLN1 fibulin 1
FERMT2 fermitin family member 2
FOXN3 forkhead box N3
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GREM1 gremlin 1, DAN family BMP antagonist
IL7R interleukin 7 receptor
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
IVNS1ABP influenza virus NS1A binding protein
KCTD12 potassium channel tetramerization domain containing 12
LDLR low density lipoprotein receptor
LMNA lamin A/C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDFIC MyoD family inhibitor domain containing
MEIS1 Meis homeobox 1
MTMR11 myotubularin related protein 11
NCF2 neutrophil cytosolic factor 2
NT5E 5'-nucleotidase, ecto (CD73)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PLS1 plastin 1
PXN paxillin
RAB2A RAB2A, member RAS oncogene family
RIN2 Ras and Rab interactor 2
SLC38A1 solute carrier family 38, member 1
SMYD3 SET and MYND domain containing 3
SVIL supervillin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP1 TIMP metallopeptidase inhibitor 1
TOMM34 translocase of outer mitochondrial membrane 34
VGLL4 vestigial-like family member 4
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
AK4 adenylate kinase 4
AUTS2 autism susceptibility candidate 2
CCNA2 cyclin A2
CD200 CD200 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL1A2 collagen, type I, alpha 2
CRYAB crystallin, alpha B
DHFR dihydrofolate reductase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
IFITM3 interferon induced transmembrane protein 3
IL1R2 interleukin 1 receptor, type II
LTF lactotransferrin
MCM3 minichromosome maintenance complex component 3
NID1 nidogen 1
PFKL phosphofructokinase, liver
PROM1 prominin 1
RAD23B RAD23 homolog B (S. cerevisiae)
RBP4 retinol binding protein 4, plasma
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLN sarcolipin
SQLE squalene epoxidase
TF transferrin
TTN titin
TUBB4B tubulin, beta 4B class IVb