BRD-K47764688_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K47764688_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELF2 CUGBP, Elav-like family member 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
DEPTOR DEP domain containing MTOR-interacting protein
EGFL6 EGF-like-domain, multiple 6
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GOLGA4 golgin A4
HMGB3 high mobility group box 3
HOPX HOP homeobox
IL1R1 interleukin 1 receptor, type I
IL2RG interleukin 2 receptor, gamma
ITK IL2-inducible T-cell kinase
ITM2A integral membrane protein 2A
KIAA1109 KIAA1109
KLK8 kallikrein-related peptidase 8
MATN2 matrilin 2
MGLL monoglyceride lipase
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NID2 nidogen 2 (osteonidogen)
NOTCH2NL notch 2 N-terminal like
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
RALB v-ral simian leukemia viral oncogene homolog B
SERINC5 serine incorporator 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
TBC1D4 TBC1 domain family, member 4
TDO2 tryptophan 2,3-dioxygenase
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TMEM131 transmembrane protein 131
TNC tenascin C
TTC3 tetratricopeptide repeat domain 3
TXN thioredoxin
UBE2A ubiquitin-conjugating enzyme E2A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
BAX BCL2-associated X protein
BCL6 B-cell CLL/lymphoma 6
BSG basigin (Ok blood group)
C10ORF10 chromosome 10 open reading frame 10
CFB complement factor B
CRELD2 cysteine-rich with EGF-like domains 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PEBP1 phosphatidylethanolamine binding protein 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PSPH phosphoserine phosphatase
RHOB ras homolog family member B
RPL37A ribosomal protein L37a
RSL1D1 ribosomal L1 domain containing 1
SDC1 syndecan 1
SHB Src homology 2 domain containing adaptor protein B
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX9 SRY (sex determining region Y)-box 9
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STXBP2 syntaxin binding protein 2
TEAD4 TEA domain family member 4
TM4SF1 transmembrane 4 L six family member 1
ZFP36L2 ZFP36 ring finger protein-like 2