BRD-K46056750_AZD-7762_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K46056750_AZD-7762_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ANXA2 annexin A2
APOLD1 apolipoprotein L domain containing 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CENPE centromere protein E, 312kDa
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
EMP3 epithelial membrane protein 3
GSTP1 glutathione S-transferase pi 1
HDAC6 histone deacetylase 6
HOPX HOP homeobox
IER5 immediate early response 5
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LDLR low density lipoprotein receptor
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP7 microtubule-associated protein 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SQLE squalene epoxidase
STC2 stanniocalcin 2
TES testin LIM domain protein
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD2 abhydrolase domain containing 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGAP29 Rho GTPase activating protein 29
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C7 complement component 7
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CCNE2 cyclin E2
CFI complement factor I
CRP C-reactive protein, pentraxin-related
CXCL6 chemokine (C-X-C motif) ligand 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DLD dihydrolipoamide dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EVI2B ecotropic viral integration site 2B
FADS3 fatty acid desaturase 3
GDF15 growth differentiation factor 15
GPX3 glutathione peroxidase 3
HDAC9 histone deacetylase 9
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HILPDA hypoxia inducible lipid droplet-associated
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF8 interferon regulatory factor 8
LAMB1 laminin, beta 1
LCN2 lipocalin 2
LY6E lymphocyte antigen 6 complex, locus E
MFAP4 microfibrillar-associated protein 4
MME membrane metallo-endopeptidase
MNDA myeloid cell nuclear differentiation antigen
MX1 MX dynamin-like GTPase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLIT2 slit homolog 2 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TNC tenascin C