BRD-K46056750_AZD-7762_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K46056750_AZD-7762_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT13 acyl-CoA thioesterase 13
ADCY9 adenylate cyclase 9
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ARMCX2 armadillo repeat containing, X-linked 2
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
C1ORF115 chromosome 1 open reading frame 115
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCNG1 cyclin G1
CCNG2 cyclin G2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF2 CUGBP, Elav-like family member 2
CES2 carboxylesterase 2
CST3 cystatin C
CTSG cathepsin G
CTSV cathepsin V
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM46A family with sequence similarity 46, member A
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLH1B folate hydrolase 1B
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GOLM1 golgi membrane protein 1
GPX3 glutathione peroxidase 3
GSN gelsolin
HIST1H1C histone cluster 1, H1c
HLA-E major histocompatibility complex, class I, E
HMG20B high mobility group 20B
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1F metallothionein 1F
MVP major vault protein
NCK2 NCK adaptor protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PINK1 PTEN induced putative kinase 1
PRUNE2 prune homolog 2 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIDT2 SID1 transmembrane family, member 2
SKAP2 src kinase associated phosphoprotein 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
STXBP1 syntaxin binding protein 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ANO1 anoctamin 1, calcium activated chloride channel
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CD200 CD200 molecule
CD34 CD34 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CHN1 chimerin 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CSE1L CSE1 chromosome segregation 1-like (yeast)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPH2 DPH2 homolog (S. cerevisiae)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR2 early growth response 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM60A family with sequence similarity 60, member A
FAR2 fatty acyl CoA reductase 2
FASN fatty acid synthase
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GINS2 GINS complex subunit 2 (Psf2 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
ICAM2 intercellular adhesion molecule 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
LYPLA1 lysophospholipase I
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NELL2 NEL-like 2 (chicken)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NXN nucleoredoxin
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RANBP1 RAN binding protein 1
S100A9 S100 calcium binding protein A9
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
TFB2M transcription factor B2, mitochondrial
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
UBE2C ubiquitin-conjugating enzyme E2C