BRD-K46056750_AZD-7762_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K46056750_AZD-7762_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALDOB aldolase B, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
ANKRD36B ankyrin repeat domain 36B
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARG2 arginase 2
ASPN asporin
ASS1 argininosuccinate synthase 1
ATXN7 ataxin 7
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG2 BTG family, member 2
BTN2A2 butyrophilin, subfamily 2, member A2
C5AR1 complement component 5a receptor 1
CD14 CD14 molecule
CD209 CD209 molecule
CDC25B cell division cycle 25B
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLDN1 claudin 1
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
CLIC2 chloride intracellular channel 2
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CSF1R colony stimulating factor 1 receptor
CXADR coxsackie virus and adenovirus receptor
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND1B DENN/MADD domain containing 1B
EGR1 early growth response 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ESRP2 epithelial splicing regulatory protein 2
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP1 fatty acid binding protein 1, liver
FABP6 fatty acid binding protein 6, ileal
FGL2 fibrinogen-like 2
FZD5 frizzled class receptor 5
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEPH hephaestin
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGN4 high mobility group nucleosomal binding domain 4
HOPX HOP homeobox
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2C integral membrane protein 2C
JUP junction plakoglobin
KIF5C kinesin family member 5C
KRT20 keratin 20, type I
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MKNK1 MAP kinase interacting serine/threonine kinase 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1F metallothionein 1F
NMRK1 nicotinamide riboside kinase 1
NMU neuromedin U
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE9A phosphodiesterase 9A
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PGAP1 post-GPI attachment to proteins 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLLP plasmolipin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RAB25 RAB25, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF130 ring finger protein 130
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
ST18 suppression of tumorigenicity 18, zinc finger
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STON1 stonin 1
STXBP2 syntaxin binding protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRIB3 tribbles pseudokinase 3
TYRP1 tyrosinase-related protein 1
VAMP8 vesicle-associated membrane protein 8
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
WLS wntless Wnt ligand secretion mediator
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF292 zinc finger protein 292
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CAPNS1 calpain, small subunit 1
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CLU clusterin
COL5A1 collagen, type V, alpha 1
COL9A3 collagen, type IX, alpha 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOCK10 dedicator of cytokinesis 10
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELAVL1 ELAV like RNA binding protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
FOSL1 FOS-like antigen 1
GALE UDP-galactose-4-epimerase
GINS2 GINS complex subunit 2 (Psf2 homolog)
HK2 hexokinase 2
LIMA1 LIM domain and actin binding 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBK PDZ binding kinase
PEX11A peroxisomal biogenesis factor 11 alpha
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLSCR3 phospholipid scramblase 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFTN1 raftlin, lipid raft linker 1
RPN2 ribophorin II
RPS4Y1 ribosomal protein S4, Y-linked 1
SLPI secretory leukocyte peptidase inhibitor
SOAT1 sterol O-acyltransferase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L2 tumor protein D52-like 2
TRIM16 tripartite motif containing 16
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C