BRD-K45746021_CC-401_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K45746021_CC-401_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOR2 adiponectin receptor 2
AURKA aurora kinase A
CCNB2 cyclin B2
CSRP2 cysteine and glycine-rich protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EMP3 epithelial membrane protein 3
FHL1 four and a half LIM domains 1
FZD2 frizzled class receptor 2
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
HDAC6 histone deacetylase 6
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISCU iron-sulfur cluster assembly enzyme
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIF14 kinesin family member 14
LAMP1 lysosomal-associated membrane protein 1
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
PDGFA platelet-derived growth factor alpha polypeptide
PDZD2 PDZ domain containing 2
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
PTN pleiotrophin
RAB4A RAB4A, member RAS oncogene family
RTN1 reticulon 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TCEAL2 transcription elongation factor A (SII)-like 2
TCF4 transcription factor 4
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFS1 Wolfram syndrome 1 (wolframin)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C10ORF10 chromosome 10 open reading frame 10
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DTX4 deltex 4, E3 ubiquitin ligase
EI24 etoposide induced 2.4
FST follistatin
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GRAMD3 GRAM domain containing 3
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LIPG lipase, endothelial
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PERP PERP, TP53 apoptosis effector
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SORBS2 sorbin and SH3 domain containing 2
SVIL supervillin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
WNT5A wingless-type MMTV integration site family, member 5A