BRD-K45278408_6-fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one KUC103866N_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K45278408_6-fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one KUC103866N_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BLNK B-cell linker
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EPS8 epidermal growth factor receptor pathway substrate 8
FBXO11 F-box protein 11
GPX2 glutathione peroxidase 2
GSE1 Gse1 coiled-coil protein
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGKC immunoglobulin kappa constant
KLF4 Kruppel-like factor 4 (gut)
LY86 lymphocyte antigen 86
NQO1 NAD(P)H dehydrogenase, quinone 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SNX11 sorting nexin 11
TTC39A tetratricopeptide repeat domain 39A
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
CLEC2B C-type lectin domain family 2, member B
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
PDLIM3 PDZ and LIM domain 3
SLPI secretory leukocyte peptidase inhibitor
SOX11 SRY (sex determining region Y)-box 11
STAT1 signal transducer and activator of transcription 1, 91kDa
TAGLN transgelin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
XIST X inactive specific transcript (non-protein coding)