BRD-K45044657_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K45044657_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
BLNK B-cell linker
C1ORF54 chromosome 1 open reading frame 54
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3ORF14 chromosome 3 open reading frame 14
CD14 CD14 molecule
CD163 CD163 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA1 chloride channel accessory 1
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DST dystonin
EMP1 epithelial membrane protein 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRZB frizzled-related protein
FXYD3 FXYD domain containing ion transport regulator 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA1 gap junction protein, alpha 1, 43kDa
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
HCLS1 hematopoietic cell-specific Lyn substrate 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
OLFML3 olfactomedin-like 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PERP PERP, TP53 apoptosis effector
PFKM phosphofructokinase, muscle
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB25 RAB25, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RNASE6 ribonuclease, RNase A family, k6
RND3 Rho family GTPase 3
RTN1 reticulon 1
S100A14 S100 calcium binding protein A14
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SIK1 salt-inducible kinase 1
SLC22A18 solute carrier family 22, member 18
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSBP2 single-stranded DNA binding protein 2
STON1 stonin 1
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TBXA2R thromboxane A2 receptor
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TPD52 tumor protein D52
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
AK1 adenylate kinase 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
CADM1 cell adhesion molecule 1
CDC25A cell division cycle 25A
DHRS2 dehydrogenase/reductase (SDR family) member 2
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
LOX lysyl oxidase
MYH10 myosin, heavy chain 10, non-muscle
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
VCAN versican