BRD-K45031696_N-(4-(5-(benzo[d][1,3]dioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide Secin H3_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

29 genes differentially expressed following the BRD-K45031696_N-(4-(5-(benzo[d][1,3]dioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide Secin H3_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CLDN10 claudin 10
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCTD12 potassium channel tetramerization domain containing 12
LAMA4 laminin, alpha 4
MCM5 minichromosome maintenance complex component 5
MUC16 mucin 16, cell surface associated
RGS5 regulator of G-protein signaling 5
SPARCL1 SPARC-like 1 (hevin)
TLE2 transducin-like enhancer of split 2

decreased expression

Symbol Name
CA2 carbonic anhydrase II
CLCN3 chloride channel, voltage-sensitive 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
GHR growth hormone receptor
GLRX glutaredoxin (thioltransferase)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MYO6 myosin VI
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLS1 plastin 1
SDC2 syndecan 2
SEC62 SEC62 homolog (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TIMP3 TIMP metallopeptidase inhibitor 3