BRD-K44652183_4-(3-benzyl-1-methyl-6-oxo-2-thioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)butanoic acid KAJ-10_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

36 genes differentially expressed following the BRD-K44652183_4-(3-benzyl-1-methyl-6-oxo-2-thioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)butanoic acid KAJ-10_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA2 annexin A2
COL1A2 collagen, type I, alpha 2
CRIP2 cysteine-rich protein 2
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
HBE1 hemoglobin, epsilon 1
IGFBP7 insulin-like growth factor binding protein 7
KRT5 keratin 5, type II
LDHB lactate dehydrogenase B
MT1E metallothionein 1E
NFIB nuclear factor I/B
NRN1 neuritin 1
PLK1 polo-like kinase 1
SRPX sushi-repeat containing protein, X-linked
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCTN1 tectonic family member 1
TMEM47 transmembrane protein 47
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSPAN3 tetraspanin 3
TUSC3 tumor suppressor candidate 3
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ATP2A3 ATPase, Ca++ transporting, ubiquitous
CDA cytidine deaminase
CHIC2 cysteine-rich hydrophobic domain 2
GLRX glutaredoxin (thioltransferase)
MAP7 microtubule-associated protein 7
MMP12 matrix metallopeptidase 12
PCP4 Purkinje cell protein 4
PXDN peroxidasin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP4 secreted frizzled-related protein 4
SOCS2 suppressor of cytokine signaling 2
SULF1 sulfatase 1