BRD-K44227013_ponatinib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

125 genes differentially expressed following the BRD-K44227013_ponatinib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTB actin, beta
AIM1 absent in melanoma 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMDHD2 amidohydrolase domain containing 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CES2 carboxylesterase 2
CRTAP cartilage associated protein
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHA3 EPH receptor A3
FHL1 four and a half LIM domains 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GSN gelsolin
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
LGALS4 lectin, galactoside-binding, soluble, 4
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NDRG2 NDRG family member 2
OLFM4 olfactomedin 4
PBLD phenazine biosynthesis-like protein domain containing
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RAB40B RAB40B, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RHOB ras homolog family member B
RPL39L ribosomal protein L39-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VDAC1 voltage-dependent anion channel 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOA aldolase A, fructose-bisphosphate
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BTG3 BTG family, member 3
C8ORF4 chromosome 8 open reading frame 4
CCND2 cyclin D2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COPS4 COP9 signalosome subunit 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPCAM epithelial cell adhesion molecule
FBXL12 F-box and leucine-rich repeat protein 12
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FILIP1L filamin A interacting protein 1-like
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2A2 general transcription factor IIA, 2, 12kDa
HAL histidine ammonia-lyase
HEPH hephaestin
HIC2 hypermethylated in cancer 2
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITM2A integral membrane protein 2A
KLF10 Kruppel-like factor 10
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAPTM5 lysosomal protein transmembrane 5
LBH limb bud and heart development
LIF leukemia inhibitory factor
LIMS1 LIM and senescent cell antigen-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MYBPC1 myosin binding protein C, slow type
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NLRP2 NLR family, pyrin domain containing 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POSTN periostin, osteoblast specific factor
RGCC regulator of cell cycle
S100A6 S100 calcium binding protein A6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPARCL1 SPARC-like 1 (hevin)
SRGN serglycin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3