BRD-K44227013_ponatinib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

362 genes differentially expressed following the BRD-K44227013_ponatinib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABI1 abl-interactor 1
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMDEC1 ADAM-like, decysin 1
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
ANXA7 annexin A7
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
ARG2 arginase 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP9A ATPase, class II, type 9A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BBX bobby sox homolog (Drosophila)
BCL6 B-cell CLL/lymphoma 6
BMP6 bone morphogenetic protein 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD4 bromodomain containing 4
C1ORF115 chromosome 1 open reading frame 115
CCK cholecystokinin
CCL19 chemokine (C-C motif) ligand 19
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CHPT1 choline phosphotransferase 1
CLDN5 claudin 5
CLDN8 claudin 8
CLIC4 chloride intracellular channel 4
COASY CoA synthase
COTL1 coactosin-like F-actin binding protein 1
CREBBP CREB binding protein
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
DAXX death-domain associated protein
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DLX5 distal-less homeobox 5
DSTN destrin (actin depolymerizing factor)
DUSP14 dual specificity phosphatase 14
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FBXO11 F-box protein 11
FGFR1 fibroblast growth factor receptor 1
FOXG1 forkhead box G1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD2A GATA zinc finger domain containing 2A
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIPK1 homeodomain interacting protein kinase 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HMG20B high mobility group 20B
HOMER2 homer scaffolding protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1RN interleukin 1 receptor antagonist
IL7R interleukin 7 receptor
IST1 increased sodium tolerance 1 homolog (yeast)
JARID2 jumonji, AT rich interactive domain 2
KIF5B kinesin family member 5B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LGALS2 lectin, galactoside-binding, soluble, 2
LHX2 LIM homeobox 2
LMO4 LIM domain only 4
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LZTFL1 leucine zipper transcription factor-like 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MED13L mediator complex subunit 13-like
MEF2C myocyte enhancer factor 2C
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKRN1 makorin ring finger protein 1
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSN moesin
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1M metallothionein 1M
MYO5A myosin VA (heavy chain 12, myoxin)
NAP1L1 nucleosome assembly protein 1-like 1
NDRG1 N-myc downstream regulated 1
NOTCH2 notch 2
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PI3 peptidase inhibitor 3, skin-derived
PKP1 plakophilin 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PSAP prosaposin
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
QKI QKI, KH domain containing, RNA binding
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
RCAN1 regulator of calcineurin 1
RNF11 ring finger protein 11
RTN3 reticulon 3
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK24 serine/threonine kinase 24
STYK1 serine/threonine/tyrosine kinase 1
SUB1 SUB1 homolog (S. cerevisiae)
TCF4 transcription factor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
USP12 ubiquitin specific peptidase 12
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VGLL4 vestigial-like family member 4
VLDLR very low density lipoprotein receptor
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WBSCR22 Williams Beuren syndrome chromosome region 22
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZDHHC7 zinc finger, DHHC-type containing 7

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AK2 adenylate kinase 2
APOA2 apolipoprotein A-II
APOB apolipoprotein B
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASCC3 activating signal cointegrator 1 complex subunit 3
ASS1 argininosuccinate synthase 1
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE41 basic helix-loop-helix family, member e41
BHMT betaine--homocysteine S-methyltransferase
BPHL biphenyl hydrolase-like (serine hydrolase)
BRCA1 breast cancer 1, early onset
BTG2 BTG family, member 2
C6ORF120 chromosome 6 open reading frame 120
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCND2 cyclin D2
CD24 CD24 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKAP4 cytoskeleton-associated protein 4
CNPY2 canopy FGF signaling regulator 2
COA3 cytochrome c oxidase assembly factor 3
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
COX11 COX11 cytochrome c oxidase copper chaperone
CP ceruloplasmin (ferroxidase)
CPNE3 copine III
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DESI1 desumoylating isopeptidase 1
DHFR dihydrofolate reductase
DLK1 delta-like 1 homolog (Drosophila)
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EDNRA endothelin receptor type A
EIF5 eukaryotic translation initiation factor 5
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERBB3 erb-b2 receptor tyrosine kinase 3
ERGIC2 ERGIC and golgi 2
FABP6 fatty acid binding protein 6, ileal
FADS1 fatty acid desaturase 1
FAM127A family with sequence similarity 127, member A
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FN1 fibronectin 1
GALE UDP-galactose-4-epimerase
GAP43 growth associated protein 43
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GEMIN6 gem (nuclear organelle) associated protein 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAL histidine ammonia-lyase
HEATR1 HEAT repeat containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HOPX HOP homeobox
IFI44L interferon-induced protein 44-like
IGFBP1 insulin-like growth factor binding protein 1
IL32 interleukin 32
IPO4 importin 4
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0391 KIAA0391
L1CAM L1 cell adhesion molecule
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC100505650 uncharacterized LOC100505650
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MANSC1 MANSC domain containing 1
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MEA1 male-enhanced antigen 1
MEIS1 Meis homeobox 1
MPZL2 myelin protein zero-like 2
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRPL19 mitochondrial ribosomal protein L19
MRPL57 mitochondrial ribosomal protein L57
MRPS16 mitochondrial ribosomal protein S16
MSRB1 methionine sulfoxide reductase B1
MUC16 mucin 16, cell surface associated
MXRA7 matrix-remodelling associated 7
MYCBP MYC binding protein
NEFM neurofilament, medium polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID2 nidogen 2 (osteonidogen)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXLD1 oxidoreductase-like domain containing 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE4DIP phosphodiesterase 4D interacting protein
PEG3 paternally expressed 3
PIPOX pipecolic acid oxidase
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLN phospholamban
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PREB prolactin regulatory element binding
PRPF4 pre-mRNA processing factor 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTRH2 peptidyl-tRNA hydrolase 2
PYGL phosphorylase, glycogen, liver
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SIGMAR1 sigma non-opioid intracellular receptor 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STRA13 stimulated by retinoic acid 13
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THTPA thiamine triphosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM177 transmembrane protein 177
TMEM223 transmembrane protein 223
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPCN1 two pore segment channel 1
TPRKB TP53RK binding protein
TSPAN12 tetraspanin 12
TSPAN8 tetraspanin 8
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UMPS uridine monophosphate synthetase
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZIC1 Zic family member 1
ZNF232 zinc finger protein 232