BRD-K44227013_ponatinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K44227013_ponatinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APLP2 amyloid beta (A4) precursor-like protein 2
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
COL11A1 collagen, type XI, alpha 1
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EAPP E2F-associated phosphoprotein
EIF4B eukaryotic translation initiation factor 4B
EXPH5 exophilin 5
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FMO1 flavin containing monooxygenase 1
FOLR1 folate receptor 1 (adult)
GAS1 growth arrest-specific 1
GSE1 Gse1 coiled-coil protein
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KLF11 Kruppel-like factor 11
KRT7 keratin 7, type II
LBH limb bud and heart development
LIMCH1 LIM and calponin homology domains 1
LZTFL1 leucine zipper transcription factor-like 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
NARS asparaginyl-tRNA synthetase
NEBL nebulette
NEFL neurofilament, light polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NNT nicotinamide nucleotide transhydrogenase
NR1H2 nuclear receptor subfamily 1, group H, member 2
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PCGF2 polycomb group ring finger 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PPL periplakin
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
R3HDM2 R3H domain containing 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBBP4 retinoblastoma binding protein 4
RBBP8 retinoblastoma binding protein 8
RTN3 reticulon 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERF2 small EDRK-rich factor 2
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYNE2 spectrin repeat containing, nuclear envelope 2
TCTN1 tectonic family member 1
TKT transketolase
TRIB2 tribbles pseudokinase 2
TSC22D3 TSC22 domain family, member 3
TSPAN6 tetraspanin 6
TXNRD1 thioredoxin reductase 1
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPH aspartate beta-hydroxylase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CCND1 cyclin D1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CORO1A coronin, actin binding protein, 1A
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
EFHD2 EF-hand domain family, member D2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHB2 EPH receptor B2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3A fibronectin type III domain containing 3A
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
HOMER2 homer scaffolding protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
ITGAV integrin, alpha V
JCHAIN joining chain of multimeric IgA and IgM
KRT10 keratin 10, type I
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MOK MOK protein kinase
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NOP2 NOP2 nucleolar protein
PAX8 paired box 8
PDZRN3 PDZ domain containing ring finger 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PRKCH protein kinase C, eta
PRRC2C proline-rich coiled-coil 2C
PRSS2 protease, serine, 2 (trypsin 2)
PSME4 proteasome (prosome, macropain) activator subunit 4
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SPON1 spondin 1, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SRGN serglycin
TF transferrin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB3 tubulin, beta 3 class III
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VEGFC vascular endothelial growth factor C
VSIG4 V-set and immunoglobulin domain containing 4