BRD-K44227013_ponatinib_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

36 genes differentially expressed following the BRD-K44227013_ponatinib_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDOC aldolase C, fructose-bisphosphate
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
CBS cystathionine-beta-synthase
CRYAB crystallin, alpha B
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FDPS farnesyl diphosphate synthase
GARS glycyl-tRNA synthetase
HTRA1 HtrA serine peptidase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHGDH phosphoglycerate dehydrogenase
PLCB4 phospholipase C, beta 4
PSAT1 phosphoserine aminotransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYT1 synaptotagmin I
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
CCL2 chemokine (C-C motif) ligand 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL8 chemokine (C-X-C motif) ligand 8
FOSL1 FOS-like antigen 1
IER3 immediate early response 3
KRT15 keratin 15, type I
MYCBP MYC binding protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C