BRD-K44100512_KIN001-043_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K44100512_KIN001-043_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
COL14A1 collagen, type XIV, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FOLR1 folate receptor 1 (adult)
GPNMB glycoprotein (transmembrane) nmb
L1CAM L1 cell adhesion molecule
MEF2C myocyte enhancer factor 2C
NEU1 sialidase 1 (lysosomal sialidase)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
QPRT quinolinate phosphoribosyltransferase
RSL1D1 ribosomal L1 domain containing 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
TARS threonyl-tRNA synthetase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLIC3 chloride intracellular channel 3
CNN3 calponin 3, acidic
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
F3 coagulation factor III (thromboplastin, tissue factor)
FSTL1 follistatin-like 1
GLUL glutamate-ammonia ligase
H2AFV H2A histone family, member V
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLV2-23 immunoglobulin lambda variable 2-23
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
LEFTY1 left-right determination factor 1
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PTTG1 pituitary tumor-transforming 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS4 regulator of G-protein signaling 4
RPA3 replication protein A3, 14kDa
S100A12 S100 calcium binding protein A12
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD3 SMAD family member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TRBC1 T cell receptor beta constant 1
TXNIP thioredoxin interacting protein