BRD-K44100512_KIN001-043_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K44100512_KIN001-043_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BST2 bone marrow stromal cell antigen 2
CCND2 cyclin D2
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CTSS cathepsin S
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDIT4 DNA-damage-inducible transcript 4
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FNDC3B fibronectin type III domain containing 3B
FXYD5 FXYD domain containing ion transport regulator 5
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GSTP1 glutathione S-transferase pi 1
HMOX1 heme oxygenase 1
ICAM2 intercellular adhesion molecule 2
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO2 LIM domain only 2 (rhombotin-like 1)
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RTN3 reticulon 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
TARS threonyl-tRNA synthetase
TF transferrin
TRIB3 tribbles pseudokinase 3
WBP5 WW domain binding protein 5
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADCK3 aarF domain containing kinase 3
ADGRG6 adhesion G protein-coupled receptor G6
ANPEP alanyl (membrane) aminopeptidase
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
BACE2 beta-site APP-cleaving enzyme 2
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CD9 CD9 molecule
COL13A1 collagen, type XIII, alpha 1
COL6A1 collagen, type VI, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
ETV1 ets variant 1
GPM6B glycoprotein M6B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
ITGA6 integrin, alpha 6
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT15 keratin 15, type I
KRT8 keratin 8, type II
LAPTM4B lysosomal protein transmembrane 4 beta
MAN1C1 mannosidase, alpha, class 1C, member 1
MLPH melanophilin
MX2 MX dynamin-like GTPase 2
NDRG1 N-myc downstream regulated 1
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP93 nucleoporin 93kDa
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS2 transmembrane protease, serine 2
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1