BRD-K44100512_KIN001-043_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-K44100512_KIN001-043_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CALML4 calmodulin-like 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CD48 CD48 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CLEC7A C-type lectin domain family 7, member A
CREB1 cAMP responsive element binding protein 1
CTH cystathionine gamma-lyase
CTSS cathepsin S
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FICD FIC domain containing
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GGT1 gamma-glutamyltransferase 1
GLRX glutaredoxin (thioltransferase)
GOLGA4 golgin A4
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLF4 Kruppel-like factor 4 (gut)
LYN LYN proto-oncogene, Src family tyrosine kinase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC16 mucin 16, cell surface associated
MXI1 MAX interactor 1, dimerization protein
NARS asparaginyl-tRNA synthetase
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
PYCR1 pyrroline-5-carboxylate reductase 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RHOBTB3 Rho-related BTB domain containing 3
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZC3H12A zinc finger CCCH-type containing 12A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGAP29 Rho GTPase activating protein 29
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C7 complement component 7
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCNF cyclin F
CCNG2 cyclin G2
CD99 CD99 molecule
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLCA2 chloride channel accessory 2
CLEC11A C-type lectin domain family 11, member A
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CRIP2 cysteine-rich protein 2
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
EHD3 EH-domain containing 3
EMP1 epithelial membrane protein 1
EMP2 epithelial membrane protein 2
ENG endoglin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
F2R coagulation factor II (thrombin) receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD3 FXYD domain containing ion transport regulator 3
HMG20B high mobility group 20B
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HOXB7 homeobox B7
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRS1 insulin receptor substrate 1
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LDB2 LIM domain binding 2
LMNB1 lamin B1
LUM lumican
MALL mal, T-cell differentiation protein-like
MBNL1 muscleblind-like splicing regulator 1
MT1F metallothionein 1F
MYLK myosin light chain kinase
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NID1 nidogen 1
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLS1 plastin 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS23 protease, serine, 23
PSRC1 proline/serine-rich coiled-coil 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RGS4 regulator of G-protein signaling 4
RIN2 Ras and Rab interactor 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A2 solute carrier family 38, member 2
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
SYPL1 synaptophysin-like 1
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
WDTC1 WD and tetratricopeptide repeats 1
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1