BRD-K44100512_KIN001-043_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K44100512_KIN001-043_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BMP4 bone morphogenetic protein 4
C8ORF4 chromosome 8 open reading frame 4
CARS cysteinyl-tRNA synthetase
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CTH cystathionine gamma-lyase
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFNB2 ephrin-B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GGT1 gamma-glutamyltransferase 1
GPX2 glutathione peroxidase 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMOX1 heme oxygenase 1
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGFBP6 insulin-like growth factor binding protein 6
ISG15 ISG15 ubiquitin-like modifier
KAZN kazrin, periplakin interacting protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRN3 leucine rich repeat neuronal 3
LTBP1 latent transforming growth factor beta binding protein 1
MAB21L2 mab-21-like 2 (C. elegans)
MX1 MX dynamin-like GTPase 1
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RSAD2 radical S-adenosyl methionine domain containing 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
STMN2 stathmin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPM4 tropomyosin 4
TRAM1 translocation associated membrane protein 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ASCL1 achaete-scute family bHLH transcription factor 1
ASPN asporin
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
CENPU centromere protein U
CLDN10 claudin 10
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DST dystonin
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
F2R coagulation factor II (thrombin) receptor
FABP7 fatty acid binding protein 7, brain
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI16 interferon, gamma-inducible protein 16
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
INPP5F inositol polyphosphate-5-phosphatase F
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
KRT5 keratin 5, type II
LAMA4 laminin, alpha 4
LHFP lipoma HMGIC fusion partner
LMNB1 lamin B1
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM5 minichromosome maintenance complex component 5
MEF2C myocyte enhancer factor 2C
MOK MOK protein kinase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD2 non-SMC condensin I complex, subunit D2
NID1 nidogen 1
NUSAP1 nucleolar and spindle associated protein 1
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RDX radixin
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
TCF4 transcription factor 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VCAN versican
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
ZBTB16 zinc finger and BTB domain containing 16