BRD-K43913647_6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-1_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K43913647_6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-1_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AKR1C2 aldo-keto reductase family 1, member C2
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CD34 CD34 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK2 checkpoint kinase 2
COL1A1 collagen, type I, alpha 1
ELN elastin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
IGL immunoglobulin lambda locus
KCTD12 potassium channel tetramerization domain containing 12
LTBP3 latent transforming growth factor beta binding protein 3
MMP3 matrix metallopeptidase 3
MT1E metallothionein 1E
MT1F metallothionein 1F
MYO1B myosin IB
NOLC1 nucleolar and coiled-body phosphoprotein 1
PEBP1 phosphatidylethanolamine binding protein 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
RFC5 replication factor C (activator 1) 5, 36.5kDa
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SRSF7 serine/arginine-rich splicing factor 7
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)

decreased expression

Symbol Name
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BASP1 brain abundant, membrane attached signal protein 1
BLVRB biliverdin reductase B
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNG2 cyclin G2
CD47 CD47 molecule
CDK19 cyclin-dependent kinase 19
CXCL11 chemokine (C-X-C motif) ligand 11
FLRT3 fibronectin leucine rich transmembrane protein 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GLRX glutaredoxin (thioltransferase)
KRT19 keratin 19, type I
LRP10 low density lipoprotein receptor-related protein 10
MAP7 microtubule-associated protein 7
PCP4 Purkinje cell protein 4
RAD23B RAD23 homolog B (S. cerevisiae)
SLAMF7 SLAM family member 7
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TARP TCR gamma alternate reading frame protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGM4 transglutaminase 4
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
WT1 Wilms tumor 1