BRD-K43913647_6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-1_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K43913647_6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-1_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANXA6 annexin A6
BTN3A2 butyrophilin, subfamily 3, member A2
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DUSP4 dual specificity phosphatase 4
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
GAA glucosidase, alpha; acid
GPX1 glutathione peroxidase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KLF6 Kruppel-like factor 6
LARS leucyl-tRNA synthetase
MAP1B microtubule-associated protein 1B
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRIP1 nuclear receptor interacting protein 1
PDLIM1 PDZ and LIM domain 1
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
PLTP phospholipid transfer protein
PYGL phosphorylase, glycogen, liver
RABAC1 Rab acceptor 1 (prenylated)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFN stratifin
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
VIM vimentin
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZBTB20 zinc finger and BTB domain containing 20
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
CA2 carbonic anhydrase II
CDK1 cyclin-dependent kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
EGR2 early growth response 2
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GTF2A2 general transcription factor IIA, 2, 12kDa
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGL immunoglobulin lambda locus
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
MAOA monoamine oxidase A
MUC1 mucin 1, cell surface associated
MYOF myoferlin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
TPD52L1 tumor protein D52-like 1
XBP1 X-box binding protein 1