BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_VCAP_24.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

267 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_VCAP_24.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ACVR1 activin A receptor, type I
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
APOLD1 apolipoprotein L domain containing 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
COL15A1 collagen, type XV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPRS glutamyl-prolyl-tRNA synthetase
EVI2B ecotropic viral integration site 2B
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM13A family with sequence similarity 13, member A
FBLN2 fibulin 2
FHL1 four and a half LIM domains 1
FMO3 flavin containing monooxygenase 3
FRY furry homolog (Drosophila)
FYN FYN proto-oncogene, Src family tyrosine kinase
GCLC glutamate-cysteine ligase, catalytic subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPC3 glypican 3
GPC4 glypican 4
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP2 GTP binding protein 2
HBB hemoglobin, beta
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INHBB inhibin, beta B
INHBE inhibin, beta E
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KRT7 keratin 7, type II
KRT8 keratin 8, type II
KYNU kynureninase
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
LYZ lysozyme
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MB myoglobin
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYOF myoferlin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PAWR PRKC, apoptosis, WT1, regulator
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PXDC1 PX domain containing 1
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN4 reticulon 4
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPT10 septin 10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TF transferrin
TFF1 trefoil factor 1
TMEM47 transmembrane protein 47
TMPRSS3 transmembrane protease, serine 3
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACOT7 acyl-CoA thioesterase 7
ADI1 acireductone dioxygenase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATPIF1 ATPase inhibitory factor 1
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD320 CD320 molecule
CDC45 cell division cycle 45
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
COCH cochlin
COX7B cytochrome c oxidase subunit VIIb
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCXR dicarbonyl/L-xylulose reductase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EGR3 early growth response 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOLR1 folate receptor 1 (adult)
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GGCT gamma-glutamylcyclotransferase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPH1 heat shock 105kDa/110kDa protein 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LIG1 ligase I, DNA, ATP-dependent
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MLEC malectin
MPC2 mitochondrial pyruvate carrier 2
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MXRA7 matrix-remodelling associated 7
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPD3 non-SMC condensin II complex, subunit D3
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NEFH neurofilament, heavy polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NSG1 neuron specific gene family member 1
NUP62 nucleoporin 62kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RALGDS ral guanine nucleotide dissociation stimulator
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SEPW1 selenoprotein W, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMS spermine synthase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SORD sorbitol dehydrogenase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
TARP TCR gamma alternate reading frame protein
TECR trans-2,3-enoyl-CoA reductase
TMEM109 transmembrane protein 109
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
WWTR1 WW domain containing transcription regulator 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZWINT ZW10 interacting kinetochore protein