BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_U937_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_U937_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRL3 adhesion G protein-coupled receptor L3
AHR aryl hydrocarbon receptor
ALOX15B arachidonate 15-lipoxygenase, type B
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATXN1 ataxin 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C3AR1 complement component 3a receptor 1
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD9 CD9 molecule
CDH13 cadherin 13
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLU clusterin
CPE carboxypeptidase E
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FAIM Fas apoptotic inhibitory molecule
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FZD5 frizzled class receptor 5
GEM GTP binding protein overexpressed in skeletal muscle
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H3H histone cluster 1, H3h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
ICAM2 intercellular adhesion molecule 2
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
IL13RA1 interleukin 13 receptor, alpha 1
IL17RB interleukin 17 receptor B
JAG1 jagged 1
JUN jun proto-oncogene
LGALS3 lectin, galactoside-binding, soluble, 3
MAP3K7CL MAP3K7 C-terminal like
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MT1E metallothionein 1E
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PADI2 peptidyl arginine deiminase, type II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDLIM1 PDZ and LIM domain 1
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PXN paxillin
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SNAI2 snail family zinc finger 2
SNX13 sorting nexin 13
SOCS2 suppressor of cytokine signaling 2
STK38L serine/threonine kinase 38 like
TES testin LIM domain protein
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFRC transferrin receptor
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
VWF von Willebrand factor
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACAT1 acetyl-CoA acetyltransferase 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ADCY3 adenylate cyclase 3
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
ANKRD10 ankyrin repeat domain 10
ANXA6 annexin A6
BST2 bone marrow stromal cell antigen 2
C1GALT1C1 C1GALT1-specific chaperone 1
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CSTB cystatin B (stefin B)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECI2 enoyl-CoA delta isomerase 2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
FAM57A family with sequence similarity 57, member A
FAM98A family with sequence similarity 98, member A
FKBP1A FK506 binding protein 1A, 12kDa
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GOLM1 golgi membrane protein 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
KRT10 keratin 10, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LARP4 La ribonucleoprotein domain family, member 4
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
M6PR mannose-6-phosphate receptor (cation dependent)
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MTDH metadherin
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO6 myosin VI
NUP210 nucleoporin 210kDa
PARP1 poly (ADP-ribose) polymerase 1
PLXNC1 plexin C1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PSCA prostate stem cell antigen
PTDSS1 phosphatidylserine synthase 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB4A RAB4A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RPA1 replication protein A1, 70kDa
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC43A3 solute carrier family 43, member 3
SLC46A3 solute carrier family 46, member 3
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TM9SF2 transmembrane 9 superfamily member 2
TMCO3 transmembrane and coiled-coil domains 3
TMEM5 transmembrane protein 5
TRAPPC3 trafficking protein particle complex 3
TSPAN3 tetraspanin 3
UBE3C ubiquitin protein ligase E3C
URI1 URI1, prefoldin-like chaperone
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta