BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_TYKNU_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_TYKNU_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLIC3 chloride intracellular channel 3
COL10A1 collagen, type X, alpha 1
CPE carboxypeptidase E
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
IQGAP1 IQ motif containing GTPase activating protein 1
ISG15 ISG15 ubiquitin-like modifier
KLF6 Kruppel-like factor 6
LPL lipoprotein lipase
LRMP lymphoid-restricted membrane protein
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NOX4 NADPH oxidase 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORC1 origin recognition complex, subunit 1
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
POSTN periostin, osteoblast specific factor
RHOB ras homolog family member B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TF transferrin
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TPD52L1 tumor protein D52-like 1
TTC39A tetratricopeptide repeat domain 39A
VAMP8 vesicle-associated membrane protein 8
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BMI1 BMI1 proto-oncogene, polycomb ring finger
BZW1 basic leucine zipper and W2 domains 1
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25B cell division cycle 25B
CENPA centromere protein A
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFHD2 EF-hand domain family, member D2
EMP3 epithelial membrane protein 3
ETV5 ets variant 5
FAM162A family with sequence similarity 162, member A
FSTL1 follistatin-like 1
GSTP1 glutathione S-transferase pi 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT6B keratin 6B, type II
LBR lamin B receptor
LYPLA1 lysophospholipase I
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MYCBP MYC binding protein
NRN1 neuritin 1
PAPOLA poly(A) polymerase alpha
PCNA proliferating cell nuclear antigen
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLS3 plastin 3
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX4 peroxiredoxin 4
PRKCB protein kinase C, beta
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAE1 ribonucleic acid export 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF167 ring finger protein 167
RNH1 ribonuclease/angiogenin inhibitor 1
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SAR1A secretion associated, Ras related GTPase 1A
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPT10 septin 10
SNX6 sorting nexin 6
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM230 transmembrane protein 230
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAM1 translocation associated membrane protein 1
TRAPPC3 trafficking protein particle complex 3
TRIM2 tripartite motif containing 2
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE3C ubiquitin protein ligase E3C
VCP valosin containing protein
VKORC1 vitamin K epoxide reductase complex, subunit 1