BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_THP1_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

286 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_THP1_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALDOB aldolase B, fructose-bisphosphate
ANGPT2 angiopoietin 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP1 aquaporin 1 (Colton blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
C10ORF10 chromosome 10 open reading frame 10
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH13 cadherin 13
CFB complement factor B
CHN1 chimerin 1
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DACH1 dachshund family transcription factor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
EDNRA endothelin receptor type A
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FBP1 fructose-1,6-bisphosphatase 1
FILIP1L filamin A interacting protein 1-like
FLOT1 flotillin 1
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
FOXF2 forkhead box F2
FRZB frizzled-related protein
FSD1 fibronectin type III and SPRY domain containing 1
FXYD6 FXYD domain containing ion transport regulator 6
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GMPR guanosine monophosphate reductase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL13RA1 interleukin 13 receptor, alpha 1
INA internexin neuronal intermediate filament protein, alpha
INSM1 insulinoma-associated 1
IPO13 importin 13
ISYNA1 inositol-3-phosphate synthase 1
ITGA8 integrin, alpha 8
ITM2C integral membrane protein 2C
JAG1 jagged 1
JAG2 jagged 2
KRT20 keratin 20, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LEFTY1 left-right determination factor 1
LPAR6 lysophosphatidic acid receptor 6
MAP3K7CL MAP3K7 C-terminal like
MAP7 microtubule-associated protein 7
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MT1E metallothionein 1E
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLVAP plasmalemma vesicle associated protein
PPOX protoporphyrinogen oxidase
PRR15L proline rich 15-like
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTK2 protein tyrosine kinase 2
PTN pleiotrophin
PXN paxillin
RAI14 retinoic acid induced 14
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
RIPK4 receptor-interacting serine-threonine kinase 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAI2 snail family zinc finger 2
SNX13 sorting nexin 13
SNX7 sorting nexin 7
SOCS2 suppressor of cytokine signaling 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TBXA2R thromboxane A2 receptor
TES testin LIM domain protein
TESK1 testis-specific kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TFR2 transferrin receptor 2
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
TUBB2A tubulin, beta 2A class IIa
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A
ZNF331 zinc finger protein 331
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ACOT9 acyl-CoA thioesterase 9
AFG3L2 AFG3-like AAA ATPase 2
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ANXA5 annexin A5
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BECN1 beclin 1, autophagy related
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CELF2 CUGBP, Elav-like family member 2
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSG cathepsin G
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
EIF4E eukaryotic translation initiation factor 4E
ERGIC2 ERGIC and golgi 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GANAB glucosidase, alpha; neutral AB
GSN gelsolin
HN1L hematological and neurological expressed 1-like
HOXC6 homeobox C6
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
ICMT isoprenylcysteine carboxyl methyltransferase
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KAZN kazrin, periplakin interacting protein
KRT10 keratin 10, type I
LRIF1 ligand dependent nuclear receptor interacting factor 1
LTF lactotransferrin
LYPLA1 lysophospholipase I
MAPK6 mitogen-activated protein kinase 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED1 mediator complex subunit 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPS30 mitochondrial ribosomal protein S30
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
NNT nicotinamide nucleotide transhydrogenase
NPTN neuroplastin
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP210 nucleoporin 210kDa
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
PDLIM5 PDZ and LIM domain 5
PDS5A PDS5 cohesin associated factor A
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PRDX3 peroxiredoxin 3
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PSPH phosphoserine phosphatase
RAD23B RAD23 homolog B (S. cerevisiae)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFK riboflavin kinase
RNF6 ring finger protein (C3H2C3 type) 6
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SELT selenoprotein T
SET SET nuclear proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMS spermine synthase
SORD sorbitol dehydrogenase
SPATS2L spermatogenesis associated, serine-rich 2-like
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SRSF1 serine/arginine-rich splicing factor 1
SRSF5 serine/arginine-rich splicing factor 5
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM9SF1 transmembrane 9 superfamily member 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM5 transmembrane protein 5
TMEM87A transmembrane protein 87A
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2B topoisomerase (DNA) II beta 180kDa
TOR1AIP1 torsin A interacting protein 1
TRAM1 translocation associated membrane protein 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE3C ubiquitin protein ligase E3C
UGCG UDP-glucose ceramide glucosyltransferase
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF106 zinc finger protein 106