BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_T3M10_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_T3M10_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BPHL biphenyl hydrolase-like (serine hydrolase)
C10ORF10 chromosome 10 open reading frame 10
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM63A family with sequence similarity 63, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FXYD6 FXYD domain containing ion transport regulator 6
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GPRC5B G protein-coupled receptor, class C, group 5, member B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIPK1 homeodomain interacting protein kinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTRA1 HtrA serine peptidase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0226L KIAA0226-like
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RSRC2 arginine/serine-rich coiled-coil 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
ST18 suppression of tumorigenicity 18, zinc finger
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF165 zinc finger protein 165
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALCAM activated leukocyte cell adhesion molecule
ANXA5 annexin A5
AREG amphiregulin
ATP10D ATPase, class V, type 10D
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CRABP2 cellular retinoic acid binding protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FBN1 fibrillin 1
FGB fibrinogen beta chain
FZD7 frizzled class receptor 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GOLM1 golgi membrane protein 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP4 insulin-like growth factor binding protein 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
LAMA3 laminin, alpha 3
LBR lamin B receptor
LOX lysyl oxidase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTF lactotransferrin
LY75 lymphocyte antigen 75
MFAP5 microfibrillar associated protein 5
MLEC malectin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
OXTR oxytocin receptor
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZK1IP1 PDZK1 interacting protein 1
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
PPA2 pyrophosphatase (inorganic) 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB2A2 secretoglobin, family 2A, member 2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SORD sorbitol dehydrogenase
SRGN serglycin
TAGLN transgelin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM2 transmembrane protein 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF185 zinc finger protein 185 (LIM domain)