BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SW948_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SW948_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CARD10 caspase recruitment domain family, member 10
CCL5 chemokine (C-C motif) ligand 5
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CFH complement factor H
CHEK1 checkpoint kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EZR ezrin
FAM129A family with sequence similarity 129, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXF2 forkhead box F2
FST follistatin
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GPNMB glycoprotein (transmembrane) nmb
H1F0 H1 histone family, member 0
HBE1 hemoglobin, epsilon 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IL13RA1 interleukin 13 receptor, alpha 1
IL1R1 interleukin 1 receptor, type I
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
KRT5 keratin 5, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LRMP lymphoid-restricted membrane protein
MEIS2 Meis homeobox 2
MZB1 marginal zone B and B1 cell-specific protein
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TP63 tumor protein p63
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK2 adenylate kinase 2
ANKRD10 ankyrin repeat domain 10
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CAPZB capping protein (actin filament) muscle Z-line, beta
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CD81 CD81 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CSK c-src tyrosine kinase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DYNLL1 dynein, light chain, LC8-type 1
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
FKBP10 FK506 binding protein 10, 65 kDa
FUS FUS RNA binding protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GCH1 GTP cyclohydrolase 1
GLCE glucuronic acid epimerase
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
INTS6 integrator complex subunit 6
JMJD6 jumonji domain containing 6
KIAA0125 KIAA0125
LAMP1 lysosomal-associated membrane protein 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGST2 microsomal glutathione S-transferase 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPY neuropeptide Y
NUTF2 nuclear transport factor 2
PRDX1 peroxiredoxin 1
PRKCZ protein kinase C, zeta
PRMT1 protein arginine methyltransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD23B RAD23 homolog B (S. cerevisiae)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
RPS11 ribosomal protein S11
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBC1D4 TBC1 domain family, member 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TM9SF2 transmembrane 9 superfamily member 2
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TSPAN3 tetraspanin 3
TSPO translocator protein (18kDa)
UBE3C ubiquitin protein ligase E3C
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)