BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SW620_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SW620_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD52 CD52 molecule
CD69 CD69 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EAF2 ELL associated factor 2
EDN1 endothelin 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EZR ezrin
F11R F11 receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GPR87 G protein-coupled receptor 87
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
JUP junction plakoglobin
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MATN2 matrilin 2
MCL1 myeloid cell leukemia 1
MMP10 matrix metallopeptidase 10
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
NARFL nuclear prelamin A recognition factor-like
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC4 syndecan 4
SELE selectin E
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
STK17B serine/threonine kinase 17b
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP63 tumor protein p63
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VAMP8 vesicle-associated membrane protein 8
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBTB10 zinc finger and BTB domain containing 10
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ASCL1 achaete-scute family bHLH transcription factor 1
B3GNT1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CLIC4 chloride intracellular channel 4
CSK c-src tyrosine kinase
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DAPK1 death-associated protein kinase 1
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FKBP10 FK506 binding protein 10, 65 kDa
GDE1 glycerophosphodiester phosphodiesterase 1
GOLGA8A golgin A8 family, member A
GPC3 glypican 3
GPX1 glutathione peroxidase 1
GPX7 glutathione peroxidase 7
HMGA2 high mobility group AT-hook 2
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP4 insulin-like growth factor binding protein 4
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KIAA0485 uncharacterized LOC57235
LAMP5 lysosomal-associated membrane protein family, member 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MLEC malectin
MMP11 matrix metallopeptidase 11
NPY neuropeptide Y
PARP1 poly (ADP-ribose) polymerase 1
PBX3 pre-B-cell leukemia homeobox 3
PFN2 profilin 2
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
RBP1 retinol binding protein 1, cellular
RERE arginine-glutamic acid dipeptide (RE) repeats
SACS sacsin molecular chaperone
SDC2 syndecan 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPHS1 selenophosphate synthetase 1
SFRP1 secreted frizzled-related protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX11 SRY (sex determining region Y)-box 11
TBC1D16 TBC1 domain family, member 16
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP11 THAP domain containing 11
TSPAN3 tetraspanin 3
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C