BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SW480_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SW480_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADIRF adipogenesis regulatory factor
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
BACE2 beta-site APP-cleaving enzyme 2
BEX4 brain expressed, X-linked 4
BID BH3 interacting domain death agonist
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNA1 cyclin A1
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ESRP1 epithelial splicing regulatory protein 1
FAM69A family with sequence similarity 69, member A
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IER2 immediate early response 2
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLK10 kallikrein-related peptidase 10
LDLR low density lipoprotein receptor
LUM lumican
LYZ lysozyme
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP1 nuclear receptor interacting protein 1
PCP4 Purkinje cell protein 4
PLVAP plasmalemma vesicle associated protein
PTPRK protein tyrosine phosphatase, receptor type, K
RCAN2 regulator of calcineurin 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS1 regulator of G-protein signaling 1
RNF115 ring finger protein 115
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TF transferrin
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ASXL2 additional sex combs like transcriptional regulator 2
BTBD3 BTB (POZ) domain containing 3
CKAP4 cytoskeleton-associated protein 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFHD2 EF-hand domain family, member D2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EPN2 epsin 2
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GATA3 GATA binding protein 3
HOXC6 homeobox C6
KANK2 KN motif and ankyrin repeat domains 2
KDM5D lysine (K)-specific demethylase 5D
KIAA0125 KIAA0125
NPY neuropeptide Y
PDZK1 PDZ domain containing 1
PRSS3 protease, serine, 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
RNF167 ring finger protein 167
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RXRA retinoid X receptor, alpha
SACS sacsin molecular chaperone
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC35F2 solute carrier family 35, member F2
STX1A syntaxin 1A (brain)
TBL1X transducin (beta)-like 1X-linked
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
Funding