BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SNUC4_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SNUC4_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C4BPA complement component 4 binding protein, alpha
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CD9 CD9 molecule
CERK ceramide kinase
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CYBB cytochrome b-245, beta polypeptide
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EIF5A eukaryotic translation initiation factor 5A
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EXT1 exostosin glycosyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GRB10 growth factor receptor-bound protein 10
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2AC histone cluster 1, H2ac
HIST1H4C histone cluster 1, H4c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
JAG1 jagged 1
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LYZ lysozyme
MBNL2 muscleblind-like splicing regulator 2
MMP7 matrix metallopeptidase 7
MYO6 myosin VI
NDNF neuron-derived neurotrophic factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCDH9 protocadherin 9
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLIN2 perilipin 2
PRNP prion protein
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RBP4 retinol binding protein 4, plasma
RYBP RING1 and YY1 binding protein
SDC4 syndecan 4
SFTPC surfactant protein C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBXA2R thromboxane A2 receptor
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor

decreased expression

Symbol Name
ACLY ATP citrate lyase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX5 arachidonate 5-lipoxygenase
B3GNT1
CD81 CD81 molecule
COCH cochlin
ELOVL6 ELOVL fatty acid elongase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP6 fatty acid binding protein 6, ileal
FCGBP Fc fragment of IgG binding protein
FGFR4 fibroblast growth factor receptor 4
GAS1 growth arrest-specific 1
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
HMG20B high mobility group 20B
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL1R2 interleukin 1 receptor, type II
KIAA1033 KIAA1033
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPDC1 neural proliferation, differentiation and control, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PGBD5 piggyBac transposable element derived 5
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
RBP1 retinol binding protein 1, cellular
RPS11 ribosomal protein S11
RUNX3 runt-related transcription factor 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SKP1 S-phase kinase-associated protein 1
SLPI secretory leukocyte peptidase inhibitor
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBTB18 zinc finger and BTB domain containing 18