BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SKLU1_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

179 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SKLU1_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ARMCX3 armadillo repeat containing, X-linked 3
ASPN asporin
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C4BPA complement component 4 binding protein, alpha
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CPA3 carboxypeptidase A3 (mast cell)
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DIO1 deiodinase, iodothyronine, type I
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FAM49A family with sequence similarity 49, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GC group-specific component (vitamin D binding protein)
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MCTP1 multiple C2 domains, transmembrane 1
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH1 notch 1
NPC1 Niemann-Pick disease, type C1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB2A RAB2A, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
UPP1 uridine phosphorylase 1
VNN1 vanin 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ADI1 acireductone dioxygenase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALG8 ALG8, alpha-1,3-glucosyltransferase
APOD apolipoprotein D
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
B3GNT1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BST2 bone marrow stromal cell antigen 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHMP4A charged multivesicular body protein 4A
CHMP6 charged multivesicular body protein 6
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL6A3 collagen, type VI, alpha 3
COMMD3 COMM domain containing 3
CPVL carboxypeptidase, vitellogenic-like
CXADR coxsackie virus and adenovirus receptor
EBP emopamil binding protein (sterol isomerase)
FCGBP Fc fragment of IgG binding protein
FUCA1 fucosidase, alpha-L- 1, tissue
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DMB major histocompatibility complex, class II, DM beta
HMGA2 high mobility group AT-hook 2
HOXB7 homeobox B7
HOXC6 homeobox C6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0100 KIAA0100
KIF20A kinesin family member 20A
KLC1 kinesin light chain 1
KLHL21 kelch-like family member 21
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAGED1 melanoma antigen family D1
MAN2B1 mannosidase, alpha, class 2B, member 1
MGST2 microsomal glutathione S-transferase 2
MX2 MX dynamin-like GTPase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PGAM1 phosphoglycerate mutase 1 (brain)
PHKB phosphorylase kinase, beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPA2 pyrophosphatase (inorganic) 2
PRPF4 pre-mRNA processing factor 4
PTDSS1 phosphatidylserine synthase 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAC3D1 SAC3 domain containing 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIDT2 SID1 transmembrane family, member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC44A4 solute carrier family 44, member 4
SRGN serglycin
STXBP2 syntaxin binding protein 2
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN3 tectonic family member 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TM9SF2 transmembrane 9 superfamily member 2
TNC tenascin C
TOP2B topoisomerase (DNA) II beta 180kDa
TOX3 TOX high mobility group box family member 3
TSPAN3 tetraspanin 3
UBE3C ubiquitin protein ligase E3C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR61 WD repeat domain 61
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A