BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_RMUGS_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_RMUGS_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
H1F0 H1 histone family, member 0
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IRS2 insulin receptor substrate 2
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
POSTN periostin, osteoblast specific factor
RAD23B RAD23 homolog B (S. cerevisiae)
SOD2 superoxide dismutase 2, mitochondrial
STAT1 signal transducer and activator of transcription 1, 91kDa
TBX3 T-box 3
TCL1A T-cell leukemia/lymphoma 1A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSPYL5 TSPY-like 5

decreased expression

Symbol Name
ATF5 activating transcription factor 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTSH cathepsin H
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFCAB14 EF-hand calcium binding domain 14
FBLN1 fibulin 1
FGF9 fibroblast growth factor 9
HAL histidine ammonia-lyase
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
INA internexin neuronal intermediate filament protein, alpha
KCTD12 potassium channel tetramerization domain containing 12
KRT1 keratin 1, type II
KRT23 keratin 23, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
WFDC2 WAP four-disulfide core domain 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta